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Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer

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Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer

dc.contributor.author	Song, Xiao	es
dc.contributor.author	Zhang, Wei	es
dc.contributor.author	Zhang, Yang	es
dc.contributor.author	Zhang, Hong	es
dc.contributor.author	Fu, Zhen	es
dc.contributor.author	Ye, Jin	es
dc.contributor.author	Liu, Lai	es
dc.contributor.author	Song, Xiao	es
dc.contributor.author	Wu, Yu	es
dc.date.accessioned	2014-05-28T12:42:53Z
dc.date.available	2014-05-28T12:42:53Z
dc.date.issued	2012	es
dc.identifier.citation	Song, Xiao ; Zhang, Wei ; Zhang, Yang ; Zhang, Hong ; Fu, Zhen ; Ye, Jin ; Liu, Lai ; Song, Xiao ; Wu, Yu. Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2012, Vol. 17, No. 6: 962-968	es
dc.identifier.uri	http://hdl.handle.net/10550/35529
dc.description.abstract	Objective: To investigate the association between semaphorin 3A (SEMA 3A) and its receptor neuropilin 1 (NRP1) and the clinicopathologic characteristics of patients with tongue cancer. Study Design: Forty-three tongue squamous cell carcinoma specimens were included. Immunohistochemical staining of SEMA3A and NRP1 was performed on 15 normal tongue epithelium specimens and the 43 tumour specimens. Immunoreactivity was evaluated based on the staining intensity and distribution score. Statistical analyses were performed using Chi-squared and Spearman tests and Kaplan-Meier analysis. Results: SEMA3A was significantly down-regulated in tongue cancer compared with normal tongue (P=0.025), while NRP1 was over-expressed in tumours (P<0.001). SEMA3A expression inversely correlated with nodal metastasis (P=0.017). NRP1 expression did not correlate with any clinicopathological characteristics. Higher SEMA3A expression strongly predicted longer survival (P=0.005). Scores for the NRP1/SEMA3A ratio of >=1 predicted shorter survival (P=0.045). Conclusions: Aberrant expression of SEMA3A and its receptor NRP1 might be involved in the development of tongue cancer and might be useful prognostic markers in this tumour type.	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES