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The effect of oral contraceptives on orthodontic tooth movement in rat

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The effect of oral contraceptives on orthodontic tooth movement in rat

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dc.contributor.author Olyaee, Pooya es
dc.contributor.author Mirzakouchaki, Behnam es
dc.contributor.author Ghajar, Kavoos es
dc.contributor.author Seyyedi, Seyyed Amir es
dc.contributor.author Shalchi, Majid es
dc.contributor.author Garjani, Alireza es
dc.contributor.author Dadgar, Esmaeil es
dc.date.accessioned 2014-05-28T12:44:54Z
dc.date.available 2014-05-28T12:44:54Z
dc.date.issued 2013 es
dc.identifier.citation Olyaee, Pooya ; Mirzakouchaki, Behnam ; Ghajar, Kavoos ; Seyyedi, Seyyed Amir ; Shalchi, Majid ; Garjani, Alireza ; Dadgar, Esmaeil. The effect of oral contraceptives on orthodontic tooth movement in rat. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 1: 146-150 es
dc.identifier.uri http://hdl.handle.net/10550/35572
dc.description.abstract Introduction: The purpose of this study was to investigate the effect of ethinyl estradiol/norgestrel ? used in some oral contraceptives- on orthodontic tooth movement in Wistar rats. Material and Methods: Forty eight female three-month old Wistar rats with an average weight of 250?25gr were divided into two experimental and control groups. One week prior to appliance insertion and during the appliance therapy period, 100 mcg/kg/day of ethinyl estradiol and 1mg/kg/days of norgestrel were administered to the experimental group by gavage; meanwhile the control group received an equivalent volume of Sodium Chloride 0.9 % (Saline). Maxillary central incisors were tipped distally by insertion of springs exerting 30g force. Two, seven and fourteen days after spring insertion animals were sacrificed. The mesioincisal distance between maxillary incisors were measured. Subsequently, histological sections were prepared for histomorphometric studies. Results: 14 days after force application the orthodontic tooth movement was significantly lower in the experimental group (p<0.05). The number of osteoclasts were significantly lower in the experimental group 2, 7 and 14 days after spring insertion (p<0.05). Conclusion: Ethinyl estradiol/norgestrel (oral contraceptives) can significantly decrease the amount of tooth movement in the linear phase. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title The effect of oral contraceptives on orthodontic tooth movement in rat es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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