NAGIOS: RODERIC FUNCIONANDO

Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors

Mostra el registre parcial de l'element

dc.contributor.author Bologna-Molina, Ronell es
dc.contributor.author Mosqueda Taylor, Adalberto es
dc.contributor.author Molina Frechero, Nelly es
dc.contributor.author Mori Estevez, Ana Dolores es
dc.contributor.author Sánchez Acuña, G. es
dc.date.accessioned 2014-05-29T07:04:56Z
dc.date.available 2014-05-29T07:04:56Z
dc.date.issued 2013 es
dc.identifier.citation Bologna-Molina, Ronell ; Mosqueda Taylor, Adalberto ; Molina Frechero, Nelly ; Mori Estevez, Ana Dolores ; Sánchez Acuña, G.. Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 2: 174-179 es
dc.identifier.uri http://hdl.handle.net/10550/35584
dc.description.abstract Objectives: The aim of this study was to compare among PCNAand Ki-67 as the most reliable immunohisto chemical marker for evaluating cell proliferation in ameloblastic tumors. Study Design: Observational, retrospective, and descriptive study of a large series of ameloblastic tumors, com- D esign: Observational, retrospective, and descriptive study of a large series of ameloblastic tumors, com- esign: Observational, retrospective, and descriptive study of a large series of ameloblastic tumors, com posed of 161 ameloblastomas and four ameloblastic carcinomas, to determine and compare PCNA and Ki-67 expression using immunohistochemistry techniques. Results: When analyzing Ki-67 positivity, the desmoplastic ameloblastoma demonstrated a significantly lower proliferation rate (1.9%) compared with the solid/multicystic and unicystic ameloblastomas and ameloblastic car cinomas (p<0.05), whereas the ameloblastic carcinomas displayed a significantly higher rate compared with all of the other ameloblastomas (48.7%) (p<0.05). When analyzing cell proliferation with PCNA, we found significant differences only between the ameloblastic carcinomas (93.3%) and the desmoplastic ameloblastomas (p<0.05). When differences between the immunopositivity for PCNA and Ki-67 were compared, the percentages were higher for PCNA in all types of ameloblastomas and ameloblastic carcinomas. In all cases, the percentages were greater than 80%, whereas the immunopositivity for Ki-67 was significantly lower; for example, the ameloblastic carcinoma expressed the highest positivity and only reached 48.7%, compared to 93.3% when we used PCNA. Conclusions: In the present study, when we used the proliferation cell marker Ki-67, the percentages of positiv ity were more specific and varied among the different types of ameloblastomas, suggesting that Ki-67 is a more specific marker for the proliferation of ameloblastic tumor cells en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

Visualització       (732.7Kb)

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

Cerca a RODERIC

Cerca avançada

Visualitza

Estadístiques