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erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis

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erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis

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dc.contributor.author Jacinto Alemán, Luís Fernando es
dc.contributor.author García Carrancá, Alejandro es
dc.contributor.author Leyba Huerta, Elba Rosa es
dc.contributor.author Zenteno Galindo, Edgar es
dc.contributor.author Jiménez Farfán Farfán, María Dolores es
dc.contributor.author Hernández Guerrero, Juan Carlos es
dc.date.accessioned 2014-05-29T07:04:58Z
dc.date.available 2014-05-29T07:04:58Z
dc.date.issued 2013 es
dc.identifier.citation Jacinto Alemán, Luís Fernando ; García Carrancá, Alejandro ; Leyba Huerta, Elba Rosa ; Zenteno Galindo, Edgar ; Jiménez Farfán Farfán, María Dolores ; Hernández Guerrero, Juan Carlos. erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 2: 325-331 es
dc.identifier.uri http://hdl.handle.net/10550/35589
dc.description.abstract Objetive: The aim of this study was to determine erbB expression in normal mucosa, oral dysplasia, and invasive carcinomas developed in the hamster's buccal pouch chemical carcinogenesis model. Study design: Fifty Syrian golden hamsters were equally divided in five groups (A-E); two controls and three experi - mental group exposed to alcohol, DMBA, or both for 14 weeks. Number of tumors per cheek, volume, histological condition, erbB expression were determined and results were analyzed by the Mann-Whitney U and Dunn's test. Results: Control groups and those exposed to alcohol (A, B and C respectively) only presented clinical and histo - logical normal mucosa; while those exposed to DMBA or DMBA plus alcohol (D and E groups) developed dys - plasia and invasive carcinomas. erbB2, erbB3, and erbB4 increased their expression in alcohol-exposed mucosa, dysplasia, and invasive carcinomas. We observed a similar expression level for erbB2 in dysplasia and carcinomas; while, erbB3 and erbB4 were similar only in carcinomas. Conclusion: The DMBA and alcohol can be considered as carcinogen and promoter for oral carcinogenesis. The erbB expression is different according to their histological condition, suggesting differential participation of the erbB family in oral carcinogenesis induced by alcohol and DMBA. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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