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Immunohistochemical expression of Skp2 protein in oral nevi and melanoma

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Immunohistochemical expression of Skp2 protein in oral nevi and melanoma

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dc.contributor.author Benevenuto de Andrade, Bruno Augusto es
dc.contributor.author León, Jorge Esquiche es
dc.contributor.author Carlos, Roman es
dc.contributor.author Azañero, Wilson Delgado es
dc.contributor.author Mosqueda Taylor, Adalberto es
dc.contributor.author Almeida, Oslei Paes de es
dc.date.accessioned 2014-05-29T07:05:49Z
dc.date.available 2014-05-29T07:05:49Z
dc.date.issued 2013 es
dc.identifier.citation Benevenuto de Andrade, Bruno Augusto ; León, Jorge Esquiche ; Carlos, Roman ; Azañero, Wilson Delgado ; Mosqueda Taylor, Adalberto ; Almeida, Oslei Paes de. Immunohistochemical expression of Skp2 protein in oral nevi and melanoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 3: 388-391 es
dc.identifier.uri http://hdl.handle.net/10550/35614
dc.description.abstract Objective: The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oral nevi and 11 primary oral melanomas. Study Design: Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melano - cytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was as - sessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide. Results: Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of this protein. Conclusion: These results indicate that Skp2 protein may play a role in the development and progression of oral melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral be - nign and malignant melanocytic lesions. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Immunohistochemical expression of Skp2 protein in oral nevi and melanoma es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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