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Tutorial in oral antithrombotic therapy: Biology and dental implications

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Tutorial in oral antithrombotic therapy: Biology and dental implications

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dc.contributor.author Fakhri, Hamid Reza es
dc.contributor.author Janket, Sok Ja es
dc.contributor.author Jackson, Elizabeth A. es
dc.contributor.author Baird, Alison E. es
dc.contributor.author Dinnocenzo, Richard es
dc.contributor.author Meurman, Jukka H. es
dc.date.accessioned 2014-05-29T07:05:49Z
dc.date.available 2014-05-29T07:05:49Z
dc.date.issued 2013 es
dc.identifier.citation Fakhri, Hamid Reza ; Janket, Sok Ja ; Jackson, Elizabeth A. ; Baird, Alison E. ; Dinnocenzo, Richard ; Meurman, Jukka H.. Tutorial in oral antithrombotic therapy: Biology and dental implications. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 3: 461-472 es
dc.identifier.uri http://hdl.handle.net/10550/35616
dc.description.abstract Objectives: Recent developments of new direct oral anticoagulants that target specific clotting factors necessitate understanding of coagulation biology. The objective of this tutorial is to offer dental professionals a review of coagulation mechanisms and the pharmacodynamics of the conventional and new oral anticoagulants. Also, we summarized the dental implications of the conventional and new anticoagulants. Method : We searched Medline using search terms "antithrombotic", "antihemostasis" or "anticoagulation" and combined them with the search results of "dental", "oral surgery" or "periodontal". We restricted the results to "human" and "English". Results: The early coagulation cascade, the new cell-based coagulation model, the pharmacokinetics and pharmacodynamics of conventional antithrombotics, and new oral anticoagulants were reviewed. The new direct factor Xa inhibitors and the direct thrombin inhibitor (s), called direct oral anticoagulants (DOAs) have rapid onset of action, fast elimination on cessation, and fewer drug-drug or drug-food interactions than warfarin. However, the lack of antidotes raises concerns that some dental procedures may trigger serious hemorrhagic events. Additionally, careful perioperative withdrawal and resumption protocols for the DOAs are reviewed, because DOAs' blood levels are dependent on renal function. Also, various reversal strategies in the event of excessive bleedings are summarized. Perioperative management of dental patients taking new DOAs and conventional oral anticoagulants are also discussed. However, the perioperative strategies for DOAs are yet to be validated in randomized trials. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Tutorial in oral antithrombotic therapy: Biology and dental implications es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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