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Evaluation of socket healing in patients undergoing bisphosphonate therapy: experience of a single Institution

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Evaluation of socket healing in patients undergoing bisphosphonate therapy: experience of a single Institution

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dc.contributor.author kato, Gabriel Fukunaga es
dc.contributor.author Lopes, Rodrigo Nascimento es
dc.contributor.author Jaguar, Graziella Chagas es
dc.contributor.author Silva, Ana Paula es
dc.contributor.author Alves, Fabio Abreu es
dc.date.accessioned 2014-05-29T07:11:29Z
dc.date.available 2014-05-29T07:11:29Z
dc.date.issued 2013 es
dc.identifier.citation kato, Gabriel Fukunaga ; Lopes, Rodrigo Nascimento ; Jaguar, Graziella Chagas ; Silva, Ana Paula ; Alves, Fabio Abreu. Evaluation of socket healing in patients undergoing bisphosphonate therapy: experience of a single Institution. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 4: 650-656 es
dc.identifier.uri http://hdl.handle.net/10550/35638
dc.description.abstract Objective: To assess the clinical features of exodontias performed in cancer patients who have been receiving intravenous bisphosphonates (BPs). Study Design: This is a retrospective cohort study using a sample of 20 patients receiving BPs who had 62 teeth extracted. An univariate analysis was applied to calculate socket healing time (HT), comparing among exodontias performed according to cause, such as periodontal disease or caries, type of BP, and use of corticosteroid. In order to analyze the influence of each variable on HT, multiple statistical analyses were performed through logistic multiple regression. Results: From the 62 tooth extractions performed, 5 exodontias had evolved to 4 sites of bisphosphonate-related osteonecrosis of the jaws (BOJ). Of another 57 exodontias without development of BOJ, HT was significantly better for tooth extraction performed in patients receiving corticosteroid (p= .01), for tooth extracted due to caries (p= .04), and for extractions under pamidronate (p= .03). Sockets after exodontias due to periodontal diseases had OR= 5.22 (95% CI 1.73-133.66, p=0.01) for delayed HT, exodontias performed under corticosteroid use had OR=0.04 (95% CI 0.01-0.40, p<0.001), and exodontias performed under zoledronate had OR=0.31 (95% CI 0.08- 1.25, p=0.10). Conclusions: Exodontias performed in patients under BP therapy had a low rate of BOJ occurrence. Zoledronate and periodontal diseases influence delayed socket healing. Adjuvant antibiotics could be relevant procedures aimed at reducing the risk of BOJ development. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Evaluation of socket healing in patients undergoing bisphosphonate therapy: experience of a single Institution es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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