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Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma-A correlation with clinicopathological features

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Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma-A correlation with clinicopathological features

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dc.contributor.author Patil, Gururaj B. es
dc.contributor.author Hallikeri, Kaveri S es
dc.contributor.author Balappanavar, Aswini Y. es
dc.contributor.author Hongal, Sudheer G. es
dc.contributor.author Sanjaya, PR es
dc.contributor.author Sagari, Sheetalkumar G. es
dc.date.accessioned 2014-05-29T07:11:32Z
dc.date.available 2014-05-29T07:11:32Z
dc.date.issued 2013 es
dc.identifier.citation Patil, Gururaj B. ; Hallikeri, Kaveri S ; Balappanavar, Aswini Y. ; Hongal, Sudheer G. ; Sanjaya, PR ; Sagari, Sheetalkumar G.. Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma-A correlation with clinicopathological features. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 4: 585-590 es
dc.identifier.uri http://hdl.handle.net/10550/35646
dc.description.abstract Background: Nuclear localization of cyclin B1 is an indicator for cells undergoing mitotic division, and the overexpression has shown promising results as a good prognostic predictor for patients of squamous cell carcinoma (SCC). Cyclin B1 overexpression among histological grades of conventional oral squamous cell carcinoma (COSCC), as well as comparison with verrucous carcinoma (VC) has been less investigated. Study Design: Immunohistochemical expression of cyclin B1 was compared with various clinicopathological features in 30 primary COSCC and 31 primary VC cases. Result: Cyclin B1 showed significant overexpression for some clinical features for both the variants of oral squamous cell carcinoma. In histopathological variants, statistical significance was observed among grades of COSCC, as well as COSCC and its grades with VC. The concomitant increase in cyclin B1 overexpression from VC to grades COSCC was observed. Conclusion: Our study findings draw attention to cyclin B1 overexpression is involved in early carcinogenesis, cell differentiation and tumor proliferation. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma-A correlation with clinicopathological features es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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