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Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats

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Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats

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dc.contributor.author Gottberg, Beatriz es
dc.contributor.author Berné, Jeanily es
dc.contributor.author Quiñónez, Belkis es
dc.contributor.author Solórzano Navarro, Eduvigis es
dc.date.accessioned 2014-07-04T07:53:26Z
dc.date.available 2014-07-04T07:53:26Z
dc.date.issued 2014 es
dc.identifier.citation Gottberg, Beatriz ; Berné, Jeanily ; Quiñónez, Belkis ; Solórzano Navarro, Eduvigis. Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 1: 38-43 es
dc.identifier.uri http://hdl.handle.net/10550/36848
dc.description.abstract Amoxicillin is an antibiotic widely prescribed; its most frequent side effects are gastrointestinal disorders and hypersensitivity reactions. Over the last 10 years studies have been published which suggest that amoxicillin may cause dental alterations similar to dental fluorosis. Never the less, the results are not conclusive, this is why it was planned the need to make controlled studies on test animals. Objectives: The purpose of this study was to determine the effect produced by amoxicillin prenatal administration on dental enamel in Wistar rats. Study Design: 12 pregnant adult rats were used distributed into five different groups: witness control (n=2) didn't get any treatment; negative control (n=2) they were prescribed with saline solution; positive control (n=3) they were prescribed with tetracycline 130 mg/kg, and two groups (n=3 and n=2) treated with amoxicillin doses of 50 and 100 mg/kg respectively. The treatments were daily administered by mouth, from the 6th gestation day to the end of gestation. Twenty five days after they were born, the offspring were sacrificed with a sodium pentobarbital overdose, the mandible was dissected and the first lower molars were gotten. The samples were fixed in 10% formaldehyde solution and clinically and histologically observed to determine any enamel disorders. Results: hypomineralization was observed in every single sample of the tetracyclic and amoxicillin treated group 100 mg/kg, meanwhile only 50% from the group administered with 50 mg/kg amoxicillin showed this histological disorder. Conclusions: the side effect caused by amoxicillin on dental enamel was doses dependent. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.medicinaoral.com/pubmed/medoralv19_i1_p38.pdf es

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