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Safety and efficacy of an intra-oral electrostimulator for the relief of dry mouth in patients with chronic graft versus host disease: case Series

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Safety and efficacy of an intra-oral electrostimulator for the relief of dry mouth in patients with chronic graft versus host disease: case Series

dc.contributor.author	Zadik, Yehuda	es
dc.contributor.author	Zeevi, Itai	es
dc.contributor.author	Luboshitz Shon, Noa	es
dc.contributor.author	Dakwar, Nasri	es
dc.contributor.author	Wolff, Andy	es
dc.contributor.author	Shapira, Michael Y.	es
dc.contributor.author	Or, Reuven	es
dc.contributor.author	Elad, Sharon	es
dc.date.accessioned	2014-07-04T07:55:26Z
dc.date.available	2014-07-04T07:55:26Z
dc.date.issued	2014	es
dc.identifier.citation	Zadik, Yehuda ; Zeevi, Itai ; Luboshitz Shon, Noa ; Dakwar, Nasri ; Wolff, Andy ; Shapira, Michael Y. ; Or, Reuven ; Elad, Sharon. Safety and efficacy of an intra-oral electrostimulator for the relief of dry mouth in patients with chronic graft versus host disease: case Series. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 3: 212-219	es
dc.identifier.uri	http://hdl.handle.net/10550/36887
dc.description.abstract	Objectives: Patients with chronic graft-versus-host disease (cGVHD) often suffer from dry mouth and oral mu - cosal lesions. The primary objective of this study was to investigate the safety of an intra-oral electrostimulator (GenNarino) in symptomatic cGVHD patients. The secondary objective was to study the impact on the salivary gland involvement of cGVHD patients. Study Design: This paper presents a case series. The study included patients treated for 4 weeks, randomly as - signed to the active device and then crossed-over to a sham-device or vice versa. The patients and clinicians were blind to the treatment delivered. Data regarding oral mucosal and salivary gland involvement were collected. Results: Six patients were included in this series. Most of the intraoral areas with manifestations of cGVHD were not in contact with the GenNarino device. Two patients developed mild mucosal lesions in areas in contact with the GenNarino during the study. However, only one of them had a change in the National Institutes of Health (NIH) score for oral cGVHD. The unstimulated and stimulated salivary flow rate increased in 4 out of the 5 pa - tients included in this analysis. Symptoms of dry mouth and general oral comfort improved. Conclusion: This study suggests that GenNarino is safe in cGVHD patients with respect to oral tissues. Furthermore the use of GenNarino resulted in subjective and objective improvements in dry mouth symptoms. A large scale study is needed to confirm the impact and safety of GenNarino on systemic cGVHD.	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Safety and efficacy of an intra-oral electrostimulator for the relief of dry mouth in patients with chronic graft versus host disease: case Series	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://www.medicinaoral.com/pubmed/medoralv19_i3_p212.pdf	es