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Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model.

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Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model.

dc.contributor.author	Jaramillo-Merchán, J.
dc.contributor.author	Jones, J.
dc.contributor.author	Ivorra Martínez, José Luis
dc.contributor.author	Pastor, D.
dc.contributor.author	Viso-León, M.C.
dc.contributor.author	Armengol, José A.
dc.contributor.author	Moltó Ruiz, María Dolores
dc.contributor.author	Geijo-Barrientos, E.
dc.contributor.author	Martínez, S.
dc.date.accessioned	2014-09-26T12:52:25Z
dc.date.available	2014-09-26T12:52:25Z
dc.date.issued	2013
dc.identifier.citation	Jaramillo-Merchán, J. Jones, J. Ivorra Martínez, José Luis Pastor, D. Viso-León, M.C. Armengol, José A. Moltó Ruiz, María Dolores Geijo-Barrientos, E. Martínez, S. 2013 Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model. Cell Death & Disease 4 e779
dc.identifier.uri	http://hdl.handle.net/10550/39013
dc.description.abstract	Demyelinating disorders such as leukodystrophies and multiple sclerosis are neurodegenerative diseases characterized by the progressive loss of myelin that may lead toward a chronic demyelination of the brain¿s white matter, impairing normal axonal conduction velocity and ultimately causing neurodegeneration. Current treatments modifying the pathological mechanisms are capable of ameliorating the disease; however, frequently, these therapies are not sufficient to repress the progressive demyelination into a chronic condition and permanent loss of function. To this end, we analyzed the effect that bone marrowderived mesenchymal stromal cell (BM-MSC) grafts exert in a chronically demyelinated mouse brain. As a result, oligodendrocyte progenitors were recruited surrounding the graft due to the expression of various trophic signals by the grafted MSCs. Although there was no significant reaction in the non-grafted side, in the grafted regions oligodendrocyte progenitors were detected. These progenitors were derived from the nearby tissue as well as from the neurogenic niches, including the subependymal zone and dentate gyrus. Once near the graft site, the cells matured to myelinating oligodendrocytes. Finally, electrophysiological studies demonstrated that axonal conduction velocity was significantly increased in the grafted side of the fimbria. In conclusion, we demonstrate here that in chronic demyelinated white matter, BM-MSC transplantation activates oligodendrocyte progenitors and induces remyelination in the tissue surrounding the stem cell graft.
dc.relation.ispartof	Cell Death & Disease, 2013, vol. 4, num. e779
dc.subject	Genètica
dc.title	Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model.
dc.type	journal article	es_ES
dc.date.updated	2014-09-26T12:52:25Z
dc.identifier.doi	10.1038/cddis.2013.304
dc.identifier.idgrec	097919
dc.rights.accessRights	open access	es_ES