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Telomerase and Telomere Length in Pulmonary Fibrosis

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Telomerase and Telomere Length in Pulmonary Fibrosis

dc.contributor.author	Liu, Tianju
dc.contributor.author	Ullenbruch, Matthew
dc.contributor.author	Choi, Yoon Young
dc.contributor.author	Yu, Hongfeng
dc.contributor.author	Ding, Lin
dc.contributor.author	Xaubet, Antoni
dc.contributor.author	Pereda Cervera, Javier
dc.contributor.author	Feghali Bostwick, Carol A.
dc.contributor.author	Bitterman, Peter B.
dc.contributor.author	Henke, Craig A.
dc.contributor.author	Pardo, Annie
dc.contributor.author	Selman, Moises
dc.contributor.author	Phan, Sem H.
dc.date.accessioned	2014-10-31T10:26:38Z
dc.date.available	2014-10-31T10:26:38Z
dc.date.issued	2013
dc.identifier.citation	Liu, Tianju Ullenbruch, Matthew Choi, Yoon Young Yu, Hongfeng Ding, Lin Xaubet, Antoni Pereda, Javier Feghali Bostwick, Carol A. Bitterman, Peter B. Henke, Craig A. Pardo, Annie Selman, Moises Phan, Sem H. 2013 Telomerase and Telomere Length in Pulmonary Fibrosis American Journal of Respiratory Cell and Molecular Biology 49 2 260 268
dc.identifier.uri	http://hdl.handle.net/10550/39519
dc.description.abstract	In addition to its expression in stem cells and many cancers,telomerase activity is transiently induced inmurine bleomycin (BLM)<br>induced pulmonary fibrosis with increased levels of telomerase transcriptase (TERT) expression, which is essential for fibrosis. To extend these observations to human chronic fibrotic lung disease,we investigated the expression of telomerase activity in lung fibroblasts from patients with interstitial lung diseases (ILDs), including idiopathic pulmonaryfibrosis (IPF).The resultsshowedthat telomerase activity was induced in more than 66% of IPF lung fibroblast samples, in comparison with less than 29% from control samples,some of which were obtained from lung cancer resections. Less than 4%of the humanIPF lung fibroblast samples exhibited shortened telomeres,whereas less than 6% of peripheral blood leukocyte samples from patients with IPF or hypersensitivity pneumonitis demonstrated shortened telomeres. Moreover, shortened telomeres in lategeneration telomerase RNA component knockout mice did not exert a significant effect on BLM-induced pulmonary fibrosis. In contrast, TERT knockout mice exhibited deficient fibrosis that was independent of telomere length. Finally, TERT expression was up-regulated by a histone deacetylase inhibitor, while the induction of TERT in lung fibroblastswasassociatedwiththebindingofacetylatedhistoneH3K9to the TERT promoter region. These findings indicate that significant telomerase inductionwas evident in fibroblasts from fibroticmurine lungs and a majority of IPF lung samples, whereas telomere shortening was not a common finding in the human blood and lung fibroblast samples. Notably, the animal studies indicated that the pathogenesis of pulmonary fibrosis was independent of telomere length.
dc.relation.ispartof	American Journal of Respiratory Cell and Molecular Biology, 2013, vol. 49, num. 2, p. 260-268
dc.subject	Emfisema pulmonar
dc.subject	Pulmons Malalties
dc.subject	Pulmons
dc.title	Telomerase and Telomere Length in Pulmonary Fibrosis
dc.type	journal article	es_ES
dc.date.updated	2014-10-31T10:26:38Z
dc.identifier.doi	10.1165/rcmb.2012-0514OC
dc.identifier.idgrec	086992
dc.rights.accessRights	open access	es_ES