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The role of a labial salivary gland biopsy in the diagnostic procedure for Sjögren's syndrome: a study of 94 cases

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The role of a labial salivary gland biopsy in the diagnostic procedure for Sjögren's syndrome: a study of 94 cases

dc.contributor.author	Stein-Callenfels, Dewi van	es
dc.contributor.author	Tan, Jonathan	es
dc.contributor.author	Bloemena, Elisabeth	es
dc.contributor.author	Vugt, Richard M. van	es
dc.contributor.author	Voskuyl, Alexandre E.	es
dc.contributor.author	Santana, Nathalie T.Y.	es
dc.contributor.author	Van der Waal, Isaäc	es
dc.date.accessioned	2015-01-08T12:30:58Z
dc.date.available	2015-01-08T12:30:58Z
dc.date.issued	2014	es
dc.identifier.citation	Stein-Callenfels, Dewi van ; Tan, Jonathan ; Bloemena, Elisabeth ; Vugt, Richard M. van ; Voskuyl, Alexandre E. ; Santana, Nathalie T.Y. ; Van der Waal, Isaäc. The role of a labial salivary gland biopsy in the diagnostic procedure for Sjögren's syndrome: a study of 94 cases. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 4: 372-376	es
dc.identifier.uri	http://hdl.handle.net/10550/41118
dc.description.abstract	Objectives: The purpose of the present study is to examine the role of the outcome of the labial salivary gland biopsy (LSGB) in the diagnostic procedure of patients suspected of suffering from Sjögren's syndrome (SS). Material and Methods: In a retrospective study the result of histopathological assessment of 94 consecutively taken labial salivary gland biopsies has been examined. For the diagnosis of SS the American-European Consensus Group classification (AECG, 2002) have been used. The outcome of the assessment has been discussed in relation to a recently reported classification provided by the American College of Rheumatology (ACR, 2012). Results: In the 94 LSGBs support for a diagnosis of SS has been encountered in 24 out of 26 patients with SS. In the 68 patients with a negative diagnosis of SS only six positive LSGBs were observed. The sensitivity of the labial biopsy amounted 0.92; the specificity was 0.91, while the positive predictive value and the negative predictive value amounted 0.80 and 0.97 respectively. LSGBs taken by or on the request of the departments of Rheumatology or Internal Medicine had a significant higher yield compared to LSGBs taken in other clinical departments. Conclusion s : The LSGB may play a role in the diagnostic procedure of Sjögren's syndrome when using either the AECG classification or the ACR classification. A LSGB should preferably taken after counseling for the possible presence of SS by a department of Rheumatology or Internal Medicine since the yield of such biopsies is much higher than in patients who have not been counseled by these departments prior to the taking of a LSGB. When using the ACR classification, a positive serologic result and a positive ocular test make the taking of a LSGB redundant. Only in case of a negative serologic outcome or a negative result of the ocular test a LSGB is indicated. Since both the serologic test and the ocular test carry hardly any morbidity, these tests should, indeed, be performed first before considering to take a LSGB.	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	The role of a labial salivary gland biopsy in the diagnostic procedure for Sjögren's syndrome: a study of 94 cases	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://www.medicinaoral.com/pubmed/medoralv19_i4_p372.pdf	es