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Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)

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Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)

dc.contributor.author	Bachmeier, Evelin	es
dc.contributor.author	Mazzeo, Marcelo-Adrián	es
dc.contributor.author	López, María-Marcela	es
dc.contributor.author	Linares, Jorge-Alberto	es
dc.contributor.author	Jarchum, Gustavo	es
dc.contributor.author	Wietz, Fernando-Martín	es
dc.contributor.author	Finkelberg, Ana-Beatriz	es
dc.date.accessioned	2015-01-08T12:34:04Z
dc.date.available	2015-01-08T12:34:04Z
dc.date.issued	2014	es
dc.identifier.citation	Bachmeier, Evelin ; Mazzeo, Marcelo-Adrián ; López, María-Marcela ; Linares, Jorge-Alberto ; Jarchum, Gustavo ; Wietz, Fernando-Martín ; Finkelberg, Ana-Beatriz. Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT). En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 5: 444-450	es
dc.identifier.uri	http://hdl.handle.net/10550/41142
dc.description.abstract	Objectives: High doses of chemotherapy generate DNA damage in patients undergoing bone marrow transplantation (BMT), due to the production of reactive oxygen species (ROS). In order to evaluate the local defensive eff ectiveness of the patient undergoing BMT, the concentrations of the antioxidants superoxide dismutase (SOD) and uric acid (UA) were measured in saliva. Study Design: Basal saliva samples were collected from 20 patients undergoing BMT at the Oncology Department, Sanatorio Allende (Córdoba), in the stages: initial, prior to conditioning therapy (I); middle: 7 to 10 days after BMT (M) and final stage, 30 days after discharge from isolation (F). SOD levels were determined using a RANDOX kit (RANSOD superoxide dismutase manual), and for uric acid enzymatic UOD / PAP spectrophotometric method, ( Trinder Color Kit , Wiener Lab) was used. Results: 85% of the patients developed oral mucositis. SOD concentration in the M stage was significantly higher (p<0.01) compared with stage I, and it reversed in stage F. UA concentration was significantly lower (p<0.001) in stage M compared with stage I, and in stage F it recovered the initial values. Conclusions: SOD increase in stage M coincided with the appearance of mucositis, which could be interpreted as a defensive mechanism of saliva against oxidative stress produced by chemotherapy. UA decrease in stage M would favour the development of high er degrees of mucositis.	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://www.medicinaoral.com/pubmed/medoralv19_i5_p444.pdf	es