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Immunophenotype in orofacial granulomatosis with and without Crohn's disease

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Immunophenotype in orofacial granulomatosis with and without Crohn's disease

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dc.contributor.author Gale, Gita es
dc.contributor.author Östman, Sofia es
dc.contributor.author Saalman, Robert es
dc.contributor.author Telemo, Esbjörn es
dc.contributor.author Jontell, Mats es
dc.contributor.author Hasséus, Bengt es
dc.date.accessioned 2015-01-08T12:34:40Z
dc.date.available 2015-01-08T12:34:40Z
dc.date.issued 2014 es
dc.identifier.citation Gale, Gita ; Östman, Sofia ; Saalman, Robert ; Telemo, Esbjörn ; Jontell, Mats ; Hasséus, Bengt. Immunophenotype in orofacial granulomatosis with and without Crohn's disease. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 6: 584-591 es
dc.identifier.uri http://hdl.handle.net/10550/41155
dc.description.abstract Objectives: The aim of this investigation was to characterise and compare the inflammatory infiltrates in patients with orofacial granulomatosis solely (OFG-S) and OFG with coexisting Crohn's disease (OFG+CD). Study Design: Biopsy specimens with granulomas were obtained from patients with OFG-S (n=11) and OFG+CD (n=11) and immunostained with antibodies against CD1a, CD3, CD4, CD8, CD11c, CD20, CD68 and mast cell tryptase, followed by quantitative analysis. Results: Analyses of the connective tissue revealed a significantly higher number of CD3- expressing T cells and CD11c-expressing dendritic cells in the connective tissue of patients with OFG-S compared to patients with OFG+CD. Mast cells displayed a high level of activation, although no significant difference was detected when comparing the two groups. Conclusions: The results show a different composition of the inflammatory infiltrate in patients with OFG-S compared to patients with OFG+CD. The present observations support that partly divergent immune mechanisms are involved in these two different subcategories of OFG. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Immunophenotype in orofacial granulomatosis with and without Crohn's disease es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.medicinaoral.com/pubmed/medoralv19_i6_p584.pdf es

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