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Bayesian approach to urinary ESBL-producing Escherichia coli

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Bayesian approach to urinary ESBL-producing Escherichia coli

dc.contributor.author	Sahuquillo Arce, José Miguel	es_ES
dc.contributor.author	Perpiñán Fabuel, Hèctor	es_ES
dc.contributor.author	Armero-Cervera, Carmen	es_ES
dc.contributor.author	López Quílez, Antonio	es_ES
dc.contributor.author	Selva, María	es_ES
dc.contributor.author	González, Francisco	es_ES
dc.date.accessioned	2015-01-14T12:22:03Z	es_ES
dc.date.accessioned	2015-01-19T11:46:03Z
dc.date.available	2015-01-14T12:22:03Z	es_ES
dc.date.available	2015-01-19T11:46:03Z
dc.date.issued	2014	es_ES
dc.identifier.citation	Sahuquillo Arce, José Miguel Perpiñán Fabuel, Hèctor Armero, Carmen López Quílez, Antonio Selva, María González, Francisco 2014 Bayesian approach to urinary ESBL-producing Escherichia coli Journal of Pharmacovigilance 2 3 1 5	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/41269	es_ES
dc.description.abstract	This is a retrospective study about the prevalence of ESBL-producing Escherichia coli (EEC) in urinary specimens from patients from the Comunitat Valenciana from January 2007 to December 2008. Data were retrieved from RedMIVA, and Bayesian generalized linear mixed models were considered to study the prevalence of EEC with regard to demographical and microbiological factors. The total number of infections considered was 164,502, the amount of urinary isolates was 70,827 belonging to 49,304 different patients, and 5,161 (7.3%) of the urinary isolates were EEC. Three out of four E. coli were isolated in women (76.8%), men showed higher rates of EEC (9.7% in men vs. 6.5% in women). EEC patients were, in average, 10.8 years older, and hospitalization was more frequent (9.9% vs. 6.9%). Resistance to non-β-lactams antimicrobials was higher in EEC. The rates of ciprofloxacin and co-trimoxazol resistance in EEC were 75.5% and 52.0%, respectively, whereas it ranged between 1.4-12.4% for the rest of antimicrobials.Prior EEC infection and hospitalization were the most relevant risk factors and increased the expected EEC probability approximately 400% and 50% respectively. Other infections played an important and positive role too, Enterobacteriaceae, P. aeruginosa and other bacteria being the most relevant elements. Female gender was a protective factor and reduced the risk by approximately 25% while age was an additive risk factor. Finally, an open-access web-based software was constructed to compute the probability that an E. coli in a urinary infection be an EEC from a specific combination of risk factors. This pharmacovigilance tool should prove useful to monitor and control antimicrobial resistance spread.	es_ES
dc.language.iso	eng	es_ES
dc.relation.ispartof	Journal of Pharmacovigilance, 2014, vol. 2, num. 3, p. 1-5	es_ES
dc.subject	Estadística bayesiana	es_ES
dc.subject	Microbiologia mèdica	es_ES
dc.subject	Bacteris patògens	es_ES
dc.title	Bayesian approach to urinary ESBL-producing Escherichia coli	es_ES
dc.type	journal article	es_ES
dc.date.updated	2015-01-14T12:22:03Z	es_ES
dc.identifier.doi	10.4172/2329-6887.1000133	es_ES
dc.identifier.idgrec	100496	es_ES
dc.rights.accessRights	open access	es_ES