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Pathogens and host immunity in the ancient human oral cavity

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Pathogens and host immunity in the ancient human oral cavity

dc.contributor.author	Warinner, C.
dc.contributor.author	Matias Rodrigues, J.F.
dc.contributor.author	Vyas, R.
dc.contributor.author	Trachsel, C.
dc.contributor.author	Shved, N.
dc.contributor.author	Grossman, J.
dc.contributor.author	Radini, A.
dc.contributor.author	Hancock, Y.
dc.contributor.author	Tito, R.Y.
dc.contributor.author	Fiddyment, S.
dc.contributor.author	Speller, C.
dc.contributor.author	Hendy, J.
dc.contributor.author	Charlton, S.
dc.contributor.author	Luder, H.U.
dc.contributor.author	Salazar García, Domingo Carlos
dc.contributor.author	Eppler, E.
dc.contributor.author	Seiler, R.
dc.contributor.author	Hansen, L.
dc.contributor.author	Samaniego Castruita, J.A.
dc.contributor.author	Barkow-Oesterreicher, S.
dc.contributor.author	Teoh, K.Y.
dc.contributor.author	Kelstruo, C.
dc.contributor.author	Olsen, J.V.
dc.contributor.author	Nanni, P.
dc.contributor.author	Kawai, T.
dc.contributor.author	Willerslev, E.
dc.contributor.author	Von Mering, C.
dc.contributor.author	Lewis, C.M.
dc.contributor.author	Collins, M.J.
dc.contributor.author	Gilbert, M.T.P.
dc.contributor.author	Rühli, Frank J.
dc.contributor.author	Cappellini, E.
dc.date.accessioned	2015-02-20T08:08:44Z
dc.date.available	2015-02-20T08:08:44Z
dc.date.issued	2014
dc.identifier.citation	Warinner, C. Matias Rodrigues, J.F. Vyas, R. Trachsel, C. Shved, N. Grossman, J. Radini, A. Hancock, Y. Tito, R.Y. Fiddyment, S. Speller, C. Hendy, J. Charlton, S. Luder, H.U. Salazar García, Domingo Carlos Eppler, E. Seiler, R. Hansen, L. Samaniego Castruita, J.A. Barkow-Oesterreicher, S. Teoh, K.Y. Kelstruo, C. Olsen, J.V. Nanni, P. Kawai, T. Willerslev, E. Von Mering, C. Lewis, C.M. Collins, M.J. Gilbert, M.T.P. Rühli, F. Cappellini, E. 2014 Pathogens and host immunity in the ancient human oral cavity Nature Genetics 46 336 344
dc.identifier.uri	http://hdl.handle.net/10550/42064
dc.description.abstract	Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human¿associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, `red complex¿ pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past.
dc.language.iso	eng
dc.relation.ispartof	Nature Genetics, 2014, num. 46, p. 336-344
dc.subject	Prehistòria
dc.title	Pathogens and host immunity in the ancient human oral cavity
dc.type	journal article	es_ES
dc.date.updated	2015-02-20T08:08:44Z
dc.identifier.doi	10.1038/ng.2906
dc.identifier.idgrec	101660
dc.rights.accessRights	open access	es_ES