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Differential expression of Cyclin D1 in keratin-producing odontogenic cysts

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Differential expression of Cyclin D1 in keratin-producing odontogenic cysts

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dc.contributor.author Vera-Sirera, Beatriz es
dc.contributor.author Forner Navarro, Leopoldo es
dc.contributor.author Vera Sempere, Francisco José es
dc.date.accessioned 2015-05-08T10:40:51Z
dc.date.available 2015-05-08T10:40:51Z
dc.date.issued 2015 es
dc.identifier.citation Vera-Sirera, Beatriz ; Forner Navarro, Leopoldo ; Vera Sempere, Francisco José. Differential expression of Cyclin D1 in keratin-producing odontogenic cysts. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 1: 12- es
dc.identifier.uri http://hdl.handle.net/10550/43608
dc.description.abstract Objetives: The aim of the present study was to analyze the expression levels of Cyclin D1 (CCD1), a nuclear protein that plays a crucial role in cell cycle progression, in a series of keratin-producing odontogenic cysts. Study Design: A total of 58 keratin-producing odontogenic cysts, diagnosed over ten years and classified according to the WHO 2005 criteria, were immunohistochemically analyzed in terms of CCD1 expression, which was quantified in the basal, suprabasal and intermediate/superficial epithelial compartments. The extent of immunostaining was measured as a proportion of total epithelial thickness. Quantified immunohistochemical data were correlated with clinicopathological features and clinical recurrence. Results:Keratin-producing odontogenic cysts were classified as 6 syndromic keratocystic odontogenic tumors (S-KCOT), 40 sporadic or non-syndromic KCOT (NS-KCOT) and 12 orthokeratinized odontogenic cysts (OOC). Immunohistochemically, CCD1 staining was evident predominantly in the parabasal region of all cystic lesions, but among-lesion differences were apparent, showing a clear expansion of parabasal compartment especially in the S-KCOT, followed to a lesser extent in the NS-KCOT, and being much more reduced in the OOC, which had the greatest average epithelial thickness. Conclusions: The differential expression of CCD1 noted in the present study suggests that dysregulation of cell cycle progression from G1 to the S phase contributes to the different aggressiveness of these lesions. However, CCD1 expression levels did not predict NS-KCOT recurrence, which is likely influenced by factors unrelated to lesion biology en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Differential expression of Cyclin D1 in keratin-producing odontogenic cysts es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.medicinaoral.com/pubmed/medoralv20_i1_p12.pdf es

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