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Mammary Analogue Secretory Carcinoma (MASC) of salivary gland in four Mexican patients

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Mammary Analogue Secretory Carcinoma (MASC) of salivary gland in four Mexican patients

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dc.contributor.author Serrano Arévalo, Mónica L. es
dc.contributor.author Mosqueda Taylor, Adalberto es
dc.contributor.author Domínguez Malagón, Hugo es
dc.contributor.author Michal, Michal es
dc.date.accessioned 2015-05-08T10:40:52Z
dc.date.available 2015-05-08T10:40:52Z
dc.date.issued 2015 es
dc.identifier.citation Serrano Arévalo, Mónica L. ; Mosqueda Taylor, Adalberto ; Domínguez Malagón, Hugo ; Michal, Michal. Mammary Analogue Secretory Carcinoma (MASC) of salivary gland in four Mexican patients. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 1: 7- es
dc.identifier.uri http://hdl.handle.net/10550/43620
dc.description.abstract The Clinco-pathological, immunohistochemical and molecular findings of four cases of Mammary Analogue Secretory Carcinoma (MASC) of salivary glands found in Mexico are described. The cases were extracted from 253 salivary gland tumors from a single institution in Mexico City. The 85 candidates for initial selection were: low grade mucoepidermoid carcinoma (MEC) (N=70 ), acinic cell cancinoma (AciCC) (N=14), papillary cystadenocarcinoma (N=1), and adenocarcinoma NOS (N=0). Tumors with some histological features consistent with MASC (N= 17, 6.7%) were studied by immunohistochemistry for mammaglobin, STAT5, and S-100 protein and four cases were positive (1.5%), thus the diagnosis of MASC was established, and these were submitted for molecular studies for ETV6-NTRK3 . Fusion gene was demonstrated in three cases, two had been erroneously diagnosed as poorly granulated AciCC, and one as low grade MEC with microcystic pattern. Female gender predominated (3:1); one occurred in the parotid, two in minor salivary glands and one in the submaxillary gland; infiltrating borders, atypical mitosis and lymph node metastases were seen in the parotideal tumor. Two patients with major salivary gland tumors are alive and well at 10 and 20 months respectively, the two patients with minor salivary gland tumors are lost. It can be concluded that is important to think in MASC in poorly granulated AciCC and low grade MEC with microcystic pattern. Immunohistochemisty studies confirm the diagnosis, preferentially supported by molecular studies. MASC may follow aggressive behavior or transform into a high grade neoplasm. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Mammary Analogue Secretory Carcinoma (MASC) of salivary gland in four Mexican patients es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.medicinaoral.com/pubmed/medoralv20_i1_p7.pdf es

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