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Molecular genetic study of novel biomarkers for early diagnosis of oral squamous cell carcinoma

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Molecular genetic study of novel biomarkers for early diagnosis of oral squamous cell carcinoma

dc.contributor.author	Yong Deok, Kim	es
dc.contributor.author	Eun Hyoung, Jeon	es
dc.contributor.author	Yeon Sun, Kim	es
dc.contributor.author	Kang Mi, Pang	es
dc.contributor.author	Jin Yong, Lee	es
dc.contributor.author	Sung Hwan, Cho	es
dc.contributor.author	Tae Yun, Kim	es
dc.contributor.author	Tae Sung, Park	es
dc.contributor.author	Soung Min, Kim	es
dc.contributor.author	Myung Jin, Kim	es
dc.contributor.author	Jong Ho, Lee	es
dc.date.accessioned	2015-05-27T11:47:58Z
dc.date.available	2015-05-27T11:47:58Z
dc.date.issued	2015	es
dc.identifier.citation	Yong Deok, Kim ; Eun Hyoung, Jeon ; Yeon Sun, Kim ; Kang Mi, Pang ; Jin Yong, Lee ; Sung Hwan, Cho ; Tae Yun, Kim ; Tae Sung, Park ; Soung Min, Kim ; Myung Jin, Kim ; Jong Ho, Lee. Molecular genetic study of novel biomarkers for early diagnosis of oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 2: 10-	es
dc.identifier.uri	http://hdl.handle.net/10550/44061
dc.description.abstract	Objectives: Early detection and treatment of an oral squamous cell carcinoma (OSCC) is critical because of its rapid growth, frequent lymph-node metastasis, and poor prognosis. However, no clinically-valuable methods of early diagnosis exist, and genetic analysis of OSCCs has yielded no biomarkers. Study D esign: We investigated the expression of genes associated with inflammation in OSCCs via a quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) analysis of microarray data. Tumor and normal tissues from five patients with an OSCC were used for microarray analysis. Differentially-expressed genes, identified using permutation, local pooled error (LPE), t-tests, and significance analysis of microarrays (SAM), were selected as candidate genetic markers. Results: Two groups corresponding to tissue identity were evident, implying that their differentially-expressed genes represented biological differences between tissues. Fifteen genes were identified using the Student’s paired t-test ( p< 0.05) and the SAM, with a false discovery rate of less than 0.02. Based on gene expression, these 15 genes can be used to classify an OSCC. A genetic analysis of functional networks and ontologies, validated by using a qRT-PCR analysis of the tissue samples, identified four genes, ADAM15, CDC7, IL12RB2 and TNFRSF8, that demonstrated excellent concordance with the microarray data. Conclusions: Our study demonstrated that four genes (ADAM15, CDC7, IL12RB2 and TNFRSF8) had potential as novel biomarkers for the diagnosis and the treatment of an OSCC.	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Molecular genetic study of novel biomarkers for early diagnosis of oral squamous cell carcinoma	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5081407&orden=0	es