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Hereditary gingival fibromatosis: clinical and ultrastructural features of a new family

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Hereditary gingival fibromatosis: clinical and ultrastructural features of a new family

dc.contributor.author	Pego, Sabina Pena Borges	es
dc.contributor.author	Della Coletta, Ricardo	es
dc.contributor.author	Mendes, Danilo Cangussu	es
dc.contributor.author	Faria, Paulo Rogério de	es
dc.contributor.author	Melo Filho, Mário R.	es
dc.contributor.author	Alves, Lucas Rodrigues	es
dc.contributor.author	Martelli Júnior, Hercílio	es
dc.date.accessioned	2015-05-27T11:50:19Z
dc.date.available	2015-05-27T11:50:19Z
dc.date.issued	2015	es
dc.identifier.citation	Pego, Sabina Pena Borges ; Della Coletta, Ricardo ; Mendes, Danilo Cangussu ; Faria, Paulo Rogério de ; Melo Filho, Mário R. ; Alves, Lucas Rodrigues ; Martelli Júnior, Hercílio. Hereditary gingival fibromatosis: clinical and ultrastructural features of a new family. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 2: 7-	es
dc.identifier.uri	http://hdl.handle.net/10550/44077
dc.description.abstract	Objective: This article describes the diagnosis, clinical and microscopic (histopathology and ultrastructural) features and treatment of a new family with hereditary gingival fibromatosis (HGF) and highlights the importance of this genetic condition. Study Design: To characterize the pattern of inheritance and the clinical features, members of a new family with HGF were examined. The pedigree was reliably constructed including the four latest generations of family. Hematoxylin and eosin staining and ultrastructural analysis were performed with the gingival tissue. Results: Examination of the family pedigree revealed that the patient III-2 represent the index patient of this family (initial patient with a mutation), which was transmitted to her daughter through an autosomal dominant mode of inheritance. The affected patients showed a generalized gingival overgrowth. The patient was treated with surgical procedures of gingivectomy and gingivoplasty. The diagnosis was confirmed by histopathology examination that showed a well-structured epithelium with elongated and thin papillae inserted in fibrous connective tissue with increased amount of collagen. The ultrastructural aspects of the tissue show collagen fibrils exhibiting their typically repeating banding pattern with some fibrils displaying loops at their end. Moreover, it was possible to seen in some regions fibrillar component presenting tortuous aspects and loss of the alignment among them. Conclusions: This HGF frequently resulted in both esthetic and functional problems. The genetic pattern of this Brazilian family suggested a new mutation, which was later transmitted by an autosomal dominant trait.	en_US
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Hereditary gingival fibromatosis: clinical and ultrastructural features of a new family	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5081404&orden=0	es