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Role of salivary anti-SSA/B antibodies for diagnosing primary Sjögren’s syndrome

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Role of salivary anti-SSA/B antibodies for diagnosing primary Sjögren’s syndrome

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dc.contributor.author Wei, Pan es
dc.contributor.author Li, Chunlei es
dc.contributor.author Qiang, Lu es
dc.contributor.author He, Jing es
dc.contributor.author Li, Zhanguo es
dc.contributor.author Hua, Hong es
dc.date.accessioned 2015-05-27T11:50:19Z
dc.date.available 2015-05-27T11:50:19Z
dc.date.issued 2015 es
dc.identifier.citation Wei, Pan ; Li, Chunlei ; Qiang, Lu ; He, Jing ; Li, Zhanguo ; Hua, Hong. Role of salivary anti-SSA/B antibodies for diagnosing primary Sjögren’s syndrome. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 2: 8- es
dc.identifier.uri http://hdl.handle.net/10550/44078
dc.description.abstract The diagnosis of primary Sjögren’s syndrome (pSS) is complex, and the saliva test is a potential method to improve the existing diagnostic criteria. Objective: To estimate the diagnostic accuracy of salivary anti-SSA/B antibodies in primary Sjögren’s syndrome (pSS), and to analyze their correlations with clinical and laboratory profiles. Study Design: This study enrolled 100 pSS patients and 140 non-pSS controls, including 40 rheumatoid arthritis (RA) patients, 40 systemic lupus erythematosus (SLE) patients, and 60 healthy controls. Unstimulated whole saliva and stimulated parotid saliva samples were collected from the subjects. Salivary anti-SSA/B antibodies were measured using an enzyme-linked immunosorbent assay (ELISA). Clinical and laboratory data were retrieved from the medical records. Results: In the pSS group, the sensitivity of anti-SSA and anti-SSB antibodies in whole saliva was 49% and 29%, respectively, and the specificity was 87.5% and 95%. The sensitivity of anti-SSA and anti-SSB antibodies in parotid saliva was 32% and 8%, respectively, and the specificity was 95.52% and 97.86%, respectively. In the pSS group, the diagnostic accuracy of anti-SSA/B antibodies in whole saliva was significantly higher than in parotid saliva ( p <0.05), but was significantly lower than in serum ( p <0.05). The salivary flow rate in the pSS group posi - tive for whole salivary anti-SSA was significantly lower than in the negative group ( p <0.05). The prevalence of rheumatoid factor and antinuclear factor were significantly higher in salivary SSB-positive pSS patients than in SSB-negative patients ( p <0.05). Conclusions: Compared to parotid saliva, whole saliva is a more suitable diagnostic fluid. Using salivary anti- SSA/B antibodies as a single test item is insufficient given the relatively low sensitivity. Further studies should investigate the possibility of combining tests for different salivary autoantibodies as a method for diagnosing pSS. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Role of salivary anti-SSA/B antibodies for diagnosing primary Sjögren’s syndrome es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5081405&orden=0 es

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