Objectives: The aim of this study was to evaluate the reliability and validity of the the Chinese version of the Oral Health Impact Profile for TMDs (OHIP-TMDs-C). Study Design: The OHIP-TMDs was initially translated and cross-culturally adapted to Chinese following international guidelines; then subsequently validated for the psychometric characteristics of reliability and validity. In total, 156 participants with temporomandibular disorders (TMDs) were recruited to complete the questionnaire. The reliability of the OHIP-TMDs-C was evaluated using internal consistency and test-retest methods. The validity of the OHIP-TMDs-C was analysed by construct validity and convergent validity. Construct validity was determined based on factor analysis, and convergent validity by analyzing the correlation between OHIP-TMDs-C subscale scores and the global rating of oral health question. Results: Cronbach’s alpha value (internal reliability) for the total OHIP-TMDs-C score was 0.917 and the intraclass correlation coefficient (ICC) value (test–retest reliability) was 0.899. Construct validity was determined by factor analysis, extracting five factors, accounting for 78.6% of the variance. All items had factor loadings above 0.40. In terms of convergent validity, the OHIP-TMDs-C subscale was significant correlated to the global oral health rating. Conclusions: The results suggest that the OHIP-TMDs-C has good reliability and validity and thus may be used as a valuable instrument for patients with TMDs in China.