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Age-Related Changes in Astrocytic and Ependymal Cells of the Subventricular Zone

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Age-Related Changes in Astrocytic and Ependymal Cells of the Subventricular Zone

dc.contributor.author	Capilla González, Vivian	es_ES
dc.contributor.author	Cebrián Silla, Arantxa	es_ES
dc.contributor.author	Guerrero-Cazares, Hugo	es_ES
dc.contributor.author	García Verdugo, José Manuel	es_ES
dc.contributor.author	Quiñones-Hinojosa, Alfredo	es_ES
dc.date.accessioned	2015-06-05T12:40:31Z
dc.date.available	2015-06-05T12:40:31Z
dc.date.issued	2014	es_ES
dc.identifier.citation	Glia Vol. 62 Issue 5: pp. 790-803	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44192
dc.description.abstract	Neurogenesis persists in the adult subventricular zone (SVZ) of the mammalian brain. During aging, the SVZ neurogenic capacity undergoes a progressive decline, which is attributed to a decrease in the population of neural stem cells (NSCs). However, the behavior of the NSCs that remain in the aged brain is not fully understood. Here we performed a comparative ultrastructural study of the SVZ niche of 2-month-old and 24-month-old male C57BL/6 mice, focusing on the NSC population. Using thymidine-labeling, we showed that residual NSCs in the aged SVZ divide less frequently than those in young mice. We also provided evidence that ependymal cells are not newly generated during senescence, as others studies suggest. Remarkably, both astrocytes and ependymal cells accumulated a high number of intermediate filaments and dense bodies during aging, resembling reactive cells. A better understanding of the changes occurring in the neurogenic niche during aging will allow us to develop new strategies for fighting neurological disorders linked to senescence.	es_ES
dc.subject	subventricular zone	es_ES
dc.subject	neural stem cells	es_ES
dc.subject	astrocytes	es_ES
dc.subject	ependymal cells	es_ES
dc.subject	aging	es_ES
dc.subject	ultrastructure	es_ES
dc.title	Age-Related Changes in Astrocytic and Ependymal Cells of the Subventricular Zone	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1002/glia.22642	es_ES
dc.identifier.idgrec	094954	es_ES