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Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial

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Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial

dc.contributor.author	Corella, Dolores	es_ES
dc.contributor.author	Sorlí Guerola, José Vicente	es_ES
dc.contributor.author	González, José I.	es_ES
dc.contributor.author	Ortega, Carolina	es_ES
dc.contributor.author	Fitó, Montserrat	es_ES
dc.contributor.author	Bulló, Mònica	es_ES
dc.contributor.author	Martínez-González, Miguel Ángel	es_ES
dc.contributor.author	Ros, Emilio	es_ES
dc.contributor.author	Arós, Fernando	es_ES
dc.contributor.author	Lapetra, José	es_ES
dc.contributor.author	Gómez-Gracia, Enrique	es_ES
dc.contributor.author	Serra-Majem, Lluís	es_ES
dc.contributor.author	Ruiz-Gutiérrez, Valentina	es_ES
dc.contributor.author	Fiol, Miquel	es_ES
dc.contributor.author	Coltell Simón, Óscar	es_ES
dc.contributor.author	Vinyoles, Ernest	es_ES
dc.contributor.author	Pintó, Xavier	es_ES
dc.contributor.author	Martí, Amelia	es_ES
dc.contributor.author	Saiz, Carmen	es_ES
dc.contributor.author	Ordovas, Jose M.	es_ES
dc.contributor.author	Estruch, Ramón	es_ES
dc.date.accessioned	2015-06-10T08:38:55Z
dc.date.available	2015-06-10T08:38:55Z
dc.date.issued	2014
dc.identifier.citation	Cardiovascular Diabetology Vol. 13 pp. 5-5	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44278
dc.description.abstract	BackgroundThe Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain.MethodsWe analyzed the association between the FAIM2-rs7138803 polymorphism and obesity, blood pressure and heart rate in 7,161 participants (48.3% with type 2 diabetes) in the PREDIMED study at baseline. We also explored gene-diet interactions with adherence to the Mediterranean diet (MedDiet) and examined the effects of the polymorphism on cardiovascular disease incidence per diabetes status after a median 4.8-year dietary intervention (MedDiet versus control group) follow-up.ResultsWe replicated the association between the FAIM2-rs7138803 polymorphism and greater obesity risk (OR: 1.08; 95% CI: 1.01-1.16; P = 0.011; per-A allele). Moreover, we detected novel associations of this polymorphism with higher diastolic blood pressure (DBP) and heart rate at baseline (B = 1.07; 95% CI: 0.97-1.28 bmp in AA vs G-carriers for the whole population), that remained statistically significant even after adjustment for body mass index (P = 0.012) and correction for multiple comparisons. This association was greater and statistically significant in type-2 diabetic subjects (B = 1.44: 95% CI: 0.23-2.56 bmp; P = 0.010 for AA versus G-carriers). Likewise, these findings were also observed longitudinally over 5-year follow-up. Nevertheless, we found no statistically significant gene-diet interactions with MedDiet for this trait. On analyzing myocardial infarction risk, we detected a nominally significant (P = 0.041) association in type-2 diabetic subjects (HR: 1.86; 95% CI:1.03-3.37 for AA versus G-carriers), although this association did not remain statistically significant following correction for multiple comparisons.ConclusionsWe confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive.	es_ES
dc.subject	Heart rate	es_ES
dc.subject	FAIM2	es_ES
dc.subject	Apoptosis	es_ES
dc.title	Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1186/1475-2840-13-5	es_ES
dc.identifier.idgrec	097256	es_ES