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A low cortisol response to acute stress is related to worse basal memory performance in older people

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A low cortisol response to acute stress is related to worse basal memory performance in older people

dc.contributor.author	Almela Zamorano, Mercedes	es_ES
dc.contributor.author	Hidalgo Calvo, Vanesa	es_ES
dc.contributor.author	van der Meij, Leander	es_ES
dc.contributor.author	Pulópulos Tripiana, Matías Miguel	es_ES
dc.contributor.author	Villada Rodríguez, Carolina	es_ES
dc.contributor.author	Salvador Fernández-Montejo, Alicia	es_ES
dc.date.accessioned	2015-06-10T08:38:57Z
dc.date.available	2015-06-10T08:38:57Z
dc.date.issued	2014
dc.identifier.citation	Frontiers in Aging Neuroscience Vol. 6	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44281
dc.description.abstract	Age-related memory decline has been associated with a faulty regulation of the hypothalamus-pituitary-adrenal axis (HPA-axis). The aim of this study was to investigate whether the magnitude of the stress-induced cortisol increase is related to memory performance when memory is measured in non-stressful conditions. To do so, declarative and working memory performance were measured in 31 men and 35 women between 55 and 77 years of age. On a different day, the magnitude of their cortisol response to acute psychosocial stress was measured. The relationship between the cortisol response and memory performance was U shaped: a low cortisol response to stress was related to poorer declarative and working memory performance, whereas those who did not increase their cortisol levels and those who had the largest cortisol increase had better declarative and working memory capabilities. Sex did not moderate these relationships. These results suggest that a low cortisol response to stress could reflect a defective HPA-axis response to stressors that is accompanied by poorer memory performance. Conversely, a high cortisol response seems to reflect a correct functioning of the HPA-axis and may protect against memory deficits in the later stages of human life.	es_ES
dc.subject	cortisol	es_ES
dc.subject	declarative memory	es_ES
dc.subject	working memory	es_ES
dc.subject	HPA-axis	es_ES
dc.subject	elderly	es_ES
dc.subject	older people	es_ES
dc.subject	middle-age	es_ES
dc.subject	acute psychosocial stress	es_ES
dc.title	A low cortisol response to acute stress is related to worse basal memory performance in older people	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.3389/fnagi.2014.00157	es_ES
dc.identifier.idgrec	099335	es_ES