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Extracellular vesicles in parasitic diseases

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Extracellular vesicles in parasitic diseases

dc.contributor.author	Marcilla Díaz, Antonio	es_ES
dc.contributor.author	Martín Jaular, Lorena	es_ES
dc.contributor.author	Trelis Villanueva, María	es_ES
dc.contributor.author	de Menezes-Neto, Armando	es_ES
dc.contributor.author	Osuna, Antonio	es_ES
dc.contributor.author	Bernal, Dolores	es_ES
dc.contributor.author	Fernández Becerra, Carmen	es_ES
dc.contributor.author	Almeida, Igor C.	es_ES
dc.contributor.author	del Portillo, Hernando A.	es_ES
dc.date.accessioned	2015-06-18T07:02:05Z
dc.date.available	2015-06-18T07:02:05Z
dc.date.issued	2014	es_ES
dc.identifier.citation	Journal of Extracellular Vesicles Vol. 3	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44421
dc.description.abstract	Parasitic diseases affect billions of people and are considered a major public health issue. Close to 400 species are estimated to parasitize humans, of which around 90 are responsible for great clinical burden and mortality rates. Unfortunately, they are largely neglected as they are mainly endemic to poor regions. Of relevance to this review, there is accumulating evidence of the release of extracellular vesicles (EVs) in parasitic diseases, acting both in parasite–parasite inter-communication as well as in parasite–host interactions. EVs participate in the dissemination of the pathogen and play a role in the regulation of the host immune systems. Production of EVs from parasites or parasitized cells has been described for a number of parasitic infections. In this review, we provide the most relevant findings of the involvement of EVs in intercellular communication, modulation of immune responses, involvement in pathology, and their potential as new diagnostic tools and therapeutic agents in some of the major human parasitic pathogens.	es_ES
dc.subject	extracellular vesicles	es_ES
dc.subject	microvesicles	es_ES
dc.subject	exosomes	es_ES
dc.subject	parasites	es_ES
dc.subject	protozoa	es_ES
dc.subject	helminths	es_ES
dc.title	Extracellular vesicles in parasitic diseases	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.3402/jev.v3.25040	es_ES
dc.identifier.idgrec	100836	es_ES