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Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case–control EpiGEICAM study

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Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case–control EpiGEICAM study

dc.contributor.author	Castelló, A.	es_ES
dc.contributor.author	Pollán, Marina	es_ES
dc.contributor.author	Buijsse, B.	es_ES
dc.contributor.author	Ruiz, A.	es_ES
dc.contributor.author	Casas, A. M.	es_ES
dc.contributor.author	Baena-Cañada, J. M.	es_ES
dc.contributor.author	Lope, V.	es_ES
dc.contributor.author	Antolín, S.	es_ES
dc.contributor.author	Ramos, Manuel	es_ES
dc.contributor.author	Muñoz, M.	es_ES
dc.contributor.author	Lluch Hernández, Ana	es_ES
dc.contributor.author	de Juan-Ferré, A.	es_ES
dc.contributor.author	Jara, C.	es_ES
dc.contributor.author	Jimeno, M. A.	es_ES
dc.contributor.author	Rosado, P.	es_ES
dc.contributor.author	Díaz, E.	es_ES
dc.contributor.author	Guillem, V.	es_ES
dc.contributor.author	Carrasco, Eva	es_ES
dc.contributor.author	Pérez-Gómez, B.	es_ES
dc.contributor.author	Vioque, J.	es_ES
dc.contributor.author	Boeing, H.	es_ES
dc.contributor.author	Martín, M.	es_ES
dc.date.accessioned	2015-06-18T07:02:05Z
dc.date.available	2015-06-18T07:02:05Z
dc.date.issued	2014	es_ES
dc.identifier.citation	British Journal of Cancer Vol. 111 Issue 7: pp. 1454-1462	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44422
dc.description.abstract	Background:Although there are solid findings regarding the detrimental effect of alcohol consumption, the existing evidence on the effect of other dietary factors on breast cancer (BC) risk is inconclusive. This study aimed to evaluate the association between dietary patterns and risk of BC in Spanish women, stratifying by menopausal status and tumour subtype, and to compare the results with those of Alternate Healthy Index (AHEI) and Alternate Mediterranean Diet Score (aMED).Methods:We recruited 1017 incident BC cases and 1017 matched healthy controls of similar age (±5 years) without a history of BC. The association between ‘a priori' and ‘a posteriori' developed dietary patterns and BC in general and according to menopausal status and intrinsic tumour subtypes (ER+/PR+ and HER2− HER2+ and ER−/PR− and HER2−) was evaluated using logistic and multinomial regression models.Results:Adherence to the Western dietary pattern was related to higher risk of BC (OR for the top vs the bottom quartile 1.46 (95% CI 1.06–2.01)), especially in premenopausal women (OR=1.75; 95% CI 1.14–2.67). In contrast, the Mediterranean pattern was related to a lower risk (OR for the top quartile vs the bottom quartile 0.56 (95% CI 0.40–0.79)). Although the deleterious effect of the Western pattern was similarly observed in all tumour subtypes, the protective effect of our Mediterranean pattern was stronger for triple-negative tumours (OR=0.32; 95% CI 0.15–0.66 and Pheterogeneity=0.04). No association was found between adherence to the Prudent pattern and BC risk. The associations between ‘a priori' indices and BC risk were less marked (OR for the top vs the bottom quartile of AHEI=0.69; 95% CI 0.51–0.94 and aMED=0.74; 95% CI 0.46–1.18)).Conclusions:Our results confirm the harmful effect of a Western diet on BC risk, and add new evidence on the benefits of a diet rich in fruits, vegetables, legumes, oily fish and vegetable oils for preventing all BC subtypes, and particularly triple-negative tumours.	es_ES
dc.subject	breast neoplasms	es_ES
dc.subject	dietary patterns	es_ES
dc.subject	aMED	es_ES
dc.subject	AHEI	es_ES
dc.subject	principal component analysis	es_ES
dc.subject	Mediterranean pattern	es_ES
dc.title	Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case–control EpiGEICAM study	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1038/bjc.2014.434	es_ES
dc.identifier.idgrec	100880	es_ES