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New Tools for Embryo Selection: Comprehensive Chromosome Screening by Array Comparative Genomic Hybridization

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New Tools for Embryo Selection: Comprehensive Chromosome Screening by Array Comparative Genomic Hybridization

dc.contributor.author	Rodrigo Vivó, Lorena	es_ES
dc.contributor.author	Mateu, Emilia	es_ES
dc.contributor.author	Mercader, Amparo	es_ES
dc.contributor.author	Cobo Cabal, Ana Cristina	es_ES
dc.contributor.author	Peinado Cervera, Vanessa	es_ES
dc.contributor.author	Milán-Sánchez, Miguel	es_ES
dc.contributor.author	Al-Asmar, Nasser	es_ES
dc.contributor.author	Campos-Galindo, Inmaculada	es_ES
dc.contributor.author	García Herrero, Sandra	es_ES
dc.contributor.author	Mir, Pere	es_ES
dc.contributor.author	Simón Vallés, Carlos	es_ES
dc.contributor.author	Rubio Lluesa, Carmen	es_ES
dc.date.accessioned	2015-06-18T07:02:05Z
dc.date.available	2015-06-18T07:02:05Z
dc.date.issued	2014	es_ES
dc.identifier.citation	BioMed Research International Vol. 2014	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44424
dc.description.abstract	The objective of this study was to evaluate the usefulness of comprehensive chromosome screening (CCS) using array comparative genomic hybridization (aCGH). The study included 1420 CCS cycles for recurrent miscarriage (n = 203); repetitive implantation failure (n = 188); severe male factor (n = 116); previous trisomic pregnancy (n = 33); and advanced maternal age (n = 880). CCS was performed in cycles with fresh oocytes and embryos (n = 774); mixed cycles with fresh and vitrified oocytes (n = 320); mixed cycles with fresh and vitrified day-2 embryos (n = 235); and mixed cycles with fresh and vitrified day-3 embryos (n = 91). Day-3 embryo biopsy was performed and analyzed by aCGH followed by day-5 embryo transfer. Consistent implantation (range: 40.5–54.2%) and pregnancy rates per transfer (range: 46.0–62.9%) were obtained for all the indications and independently of the origin of the oocytes or embryos. However, a lower delivery rate per cycle was achieved in women aged over 40 years (18.1%) due to the higher percentage of aneuploid embryos (85.3%) and lower number of cycles with at least one euploid embryo available per transfer (40.3%). We concluded that aneuploidy is one of the major factors which affect embryo implantation.	es_ES
dc.title	New Tools for Embryo Selection: Comprehensive Chromosome Screening by Array Comparative Genomic Hybridization	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1155/2014/517125	es_ES
dc.identifier.idgrec	101928	es_ES