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Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia

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Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia

dc.contributor.author	Lee, Woo-Yong	es_ES
dc.contributor.author	Sanz Ferrando, María Jesús	es_ES
dc.contributor.author	Wong, Connie H. Y.	es_ES
dc.contributor.author	Hardy, Pierre-Olivier	es_ES
dc.contributor.author	Salman-Dilgimen, Aydan	es_ES
dc.contributor.author	Moriarty, Tara J.	es_ES
dc.contributor.author	Chaconas, George	es_ES
dc.contributor.author	Marques, Adriana	es_ES
dc.contributor.author	Krawetz, Roman	es_ES
dc.contributor.author	Mody, Christopher H.	es_ES
dc.contributor.author	Kubes, Paul	es_ES
dc.date.accessioned	2015-06-18T07:05:51Z
dc.date.available	2015-06-18T07:05:51Z
dc.date.issued	2014	es_ES
dc.identifier.citation	Proceedings of the National Academy of Sciences of the United States of America Vol. 111 Issue 38: pp. 13936-13941	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44429
dc.description.abstract	SignificanceInvariant natural killer T cells (iNKT) have been found primarily patrolling inside blood vessels in the liver, where they respond to bacterial glycolipids presented by CD1d on liver macrophages. We show joint iNKT cells are localized outside of blood vessels and respond directly to the joint-homing pathogen, Borrelia burgdorferi, which causes Lyme borreliosis using multichannel spinning-disk intravital microscopy. These iNKT cells interacted with B. burgdorferi at the vessel wall and disrupted its dissemination attempts into joints. Successful penetrance of B. burgdorferi out of the vasculature and into the joint tissue was met by a lethal attack by extravascular iNKT cells through a granzyme-dependent pathway. These results suggest a critical extravascular iNKT cell immune surveillance in joints that functions as a cytotoxic barrier.	es_ES
dc.subject	joint iNKT cells	es_ES
dc.subject	granzyme B	es_ES
dc.subject	Lyme arthritis	es_ES
dc.title	Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1073/pnas.1404769111	es_ES
dc.identifier.idgrec	102349	es_ES