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Obesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study

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Obesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study

dc.contributor.author	Martínez-González, Miguel Ángel	es_ES
dc.contributor.author	García-Arellano, Ana	es_ES
dc.contributor.author	Toledo, Estefanía	es_ES
dc.contributor.author	Bes-Rastrollo, Maira	es_ES
dc.contributor.author	Bulló, Mònica	es_ES
dc.contributor.author	Corella, Dolores	es_ES
dc.contributor.author	Fitó, Montserrat	es_ES
dc.contributor.author	Ros, Emilio	es_ES
dc.contributor.author	Lamuela-Raventós, Rosa Maria	es_ES
dc.contributor.author	Rekondo, Javier	es_ES
dc.contributor.author	Gómez-Gracia, Enrique	es_ES
dc.contributor.author	Fiol, Miquel	es_ES
dc.contributor.author	Santos-Lozano, Jose Manuel	es_ES
dc.contributor.author	Serra-Majem, Lluís	es_ES
dc.contributor.author	Martínez, J. Alfredo	es_ES
dc.contributor.author	Eguaras, Sonia	es_ES
dc.contributor.author	Sáez Tormo, Guillermo	es_ES
dc.contributor.author	Pintó, Xavier	es_ES
dc.contributor.author	Estruch, Ramón	es_ES
dc.date.accessioned	2015-06-18T07:07:12Z
dc.date.available	2015-06-18T07:07:12Z
dc.date.issued	2014
dc.identifier.citation	PLoS ONE Vol. 9 Issue 7:	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44436
dc.description.abstract	BackgroundDifferent indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality.MethodsWe assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR), waist circumference (WC), body mass index (BMI) and height) with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years) and 57% were women (60 to 80 years). All of them were initially free of cardiovascular disease. The recruitment took place in 11 recruiting centers between 2003 and 2009.ResultsAfter adjusting for age, sex, smoking, diabetes, hypertension, intervention group, family history of coronary heart disease, and leisure-time physical activity, WC and WHtR were found to be directly associated with a higher mortality after 4.8 years median follow-up. The multivariable-adjusted HRs for mortality of WHtR (cut-off points: 0.60, 0.65, 0.70) were 1.02 (0.78–1.34), 1.30 (0.97–1.75) and 1.55 (1.06–2.26). When we used WC (cut-off points: 100, 105 and 110 cm), the multivariable adjusted Hazard Ratios (HRs) for mortality were 1.18 (0.88–1.59), 1.02 (0.74–1.41) and 1.57 (1.19–2.08). In all analyses, BMI exhibited weaker associations with mortality than WC or WHtR. The direct association between WHtR and overall mortality was consistent within each of the three intervention arms of the trial.ConclusionsOur study adds further support to a stronger association of abdominal obesity than BMI with total mortality among elderly subjects at high risk of cardiovascular disease. We did not find evidence to support that the PREDIMED intervention was able to counterbalance the harmful effects of increased adiposity on total mortality.Trial RegistrationControlled-Trials.com ISRCTN35739639	es_ES
dc.title	Obesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1371/journal.pone.0103246	es_ES
dc.identifier.idgrec	103810	es_ES