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Association between the rs6950982 polymorphism near the SERPINE1 gene and blood pressure and lipid parameters in a high-cardiovascular-risk population: interaction with Mediterranean diet

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Association between the rs6950982 polymorphism near the SERPINE1 gene and blood pressure and lipid parameters in a high-cardiovascular-risk population: interaction with Mediterranean diet

dc.contributor.author	Sotos Prieto, Mercedes	es_ES
dc.contributor.author	Guillén Domínguez, Marisa	es_ES
dc.contributor.author	Portolés Reparaz, Olga	es_ES
dc.contributor.author	Sorlí Guerola, José Vicente	es_ES
dc.contributor.author	González, José I.	es_ES
dc.contributor.author	Asensio, Eva M.	es_ES
dc.contributor.author	Corella, Dolores	es_ES
dc.date.accessioned	2015-06-18T12:29:19Z
dc.date.available	2015-06-18T12:29:19Z
dc.date.issued	2013	es_ES
dc.identifier.citation	Genes & Nutrition Vol. 8 Issue 4: pp. 401-409	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44465
dc.description.abstract	The SERPINE1 (serpin peptidase inhibitor, clade E, member 1) gene, better known by its previous symbol PAI-1 (plasminogen activator inhibitor 1), has been associated with cardiovascular phenotypes with differing results. Our aim was to examine the association between the rs6950982 (G > A) near the SERPINE1 gene, blood pressure (BP) and plasma lipid concentrations as well as the modulation of the polymorphism effects by adherence to Mediterranean diet (AMD). We studied 945 high-cardiovascular-risk subjects. Biochemical, clinical, dietary and genetic data (rs6950982) were obtained. We also determined the common rs1799768 (4G/5G), for checking independent effects. AMD was measured by a validated questionnaire, and four groups were considered. rs6950982 (A > G) and rs1799768 (4G/5G) were only in moderate–low linkage disequilibrium (D′ = 0.719; r2 = 0.167). The most significant associations we obtained were with rs6950982 (A > G). In males, the G allele was nominally associated with higher diastolic BP (AA: 81.5 ± 10.9, AG: 82.1 ± 11.4, GG: 85.7 ± 10.5 mmHg; Padditive = 0.030) and systolic BP (AA + AG: 141.4 ± 6.9 mmHg vs. GG: 149.8 ± 8.0 mmHg; Precessive = 0.036). In the whole population, the rs6950982 was also associated with plasma lipids. Subject with the G allele presented higher total cholesterol (Padditive = 0.016, Precessive = 0.011), low-density lipoprotein cholesterol (Padditive = 0.032, Precessive = 0.031) and triglycerides (Padditive = 0.040, Precessive = 0.029). AMD modulated the effect of rs6950982 on triglyceride concentrations (P for interaction = 0.036). Greater AMD reduced the higher triglyceride concentrations in GG subjects. No significant interactions were found for the other parameters. The rs6950982 was associated with higher BP in men and higher triglycerides in the whole population, this association being modulated by AMD.	es_ES
dc.subject	Nutrigenetics	es_ES
dc.subject	Genetics	es_ES
dc.subject	Cardiovascular	es_ES
dc.subject	Mediterranean diet	es_ES
dc.subject	Blood pressure	es_ES
dc.subject	Lipids	es_ES
dc.title	Association between the rs6950982 polymorphism near the SERPINE1 gene and blood pressure and lipid parameters in a high-cardiovascular-risk population: interaction with Mediterranean diet	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1007/s12263-012-0327-1	es_ES
dc.identifier.idgrec	089854	es_ES
dc.identifier.idgrec	084910
dc.identifier.idgrec	089538