NAGIOS: RODERIC FUNCIONANDO

Life-long spontaneous exercise does not prolong lifespan but improves health span in mice

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Life-long spontaneous exercise does not prolong lifespan but improves health span in mice

dc.contributor.author	García Vallés, Rebeca	es_ES
dc.contributor.author	Gómez Cabrera, María Carmen	es_ES
dc.contributor.author	Rodríguez-Mañas, Leocadio	es_ES
dc.contributor.author	Garcia-Garcia, Francisco J	es_ES
dc.contributor.author	Diaz, Ana	es_ES
dc.contributor.author	Noguera Salvá, Inmaculada	es_ES
dc.contributor.author	Olaso González, Gloria	es_ES
dc.contributor.author	Viña Ribes, José	es_ES
dc.date.accessioned	2015-06-18T12:29:21Z
dc.date.available	2015-06-18T12:29:21Z
dc.date.issued	2013	es_ES
dc.identifier.citation	Longevity & Healthspan Vol. 2 pp. 14-14	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44474
dc.description.abstract	BackgroundLife expectancy at birth in the first world has increased from 35 years at the beginning of the 20th century to more than 80 years now. The increase in life expectancy has resulted in an increase in age-related diseases and larger numbers of frail and dependent people. The aim of our study was to determine whether life-long spontaneous aerobic exercise affects lifespan and healthspan in mice.ResultsMale C57Bl/6J mice, individually caged, were randomly assigned to one of two groups: sedentary (n = 72) or spontaneous wheel-runners (n = 72). We evaluated longevity and several health parameters including grip strength, motor coordination, exercise capacity (VO2max) and skeletal muscle mitochondrial biogenesis. We also measured the cortical levels of the brain-derived neurotrophic factor (BDNF), a neurotrophin associated with brain plasticity. In addition, we measured systemic oxidative stress (malondialdehyde and protein carbonyl plasma levels) and the expression and activity of two genes involved in antioxidant defense in the liver (that is, glutathione peroxidase (GPx) and manganese superoxide dismutase (Mn-SOD)). Genes that encode antioxidant enzymes are considered longevity genes because their over-expression may modulate lifespan. Aging was associated with an increase in oxidative stress biomarkers and in the activity of the antioxidant enzymes, GPx and Mn-SOD, in the liver in mice. Life-long spontaneous exercise did not prolong longevity but prevented several signs of frailty (that is, decrease in strength, endurance and motor coordination). This improvement was accompanied by a significant increase in the mitochondrial biogenesis in skeletal muscle and in the cortical BDNF levels.ConclusionLife-long spontaneous exercise does not prolong lifespan but improves healthspan in mice. Exercise is an intervention that delays age-associated frailty, enhances function and can be translated into the clinic.	es_ES
dc.subject	Longevity	es_ES
dc.subject	Sarcopenia	es_ES
dc.subject	BDNF	es_ES
dc.subject	Successful aging	es_ES
dc.subject	Mitochondria	es_ES
dc.subject	Frailty	es_ES
dc.title	Life-long spontaneous exercise does not prolong lifespan but improves health span in mice	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1186/2046-2395-2-14	es_ES
dc.identifier.idgrec	090860	es_ES