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Altered Antioxidant-Oxidant Status in the Aqueous Humor and Peripheral Blood of Patients with Retinitis Pigmentosa

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Altered Antioxidant-Oxidant Status in the Aqueous Humor and Peripheral Blood of Patients with Retinitis Pigmentosa

dc.contributor.author	Martínez-Fernández de la Cámara, Cristina	es_ES
dc.contributor.author	Salom Alonso, David	es_ES
dc.contributor.author	Sequedo, María Dolores	es_ES
dc.contributor.author	Hervás, David	es_ES
dc.contributor.author	Marín-Lambíes, Cristina	es_ES
dc.contributor.author	Aller Mañas, Elena	es_ES
dc.contributor.author	Jaijo, Teresa	es_ES
dc.contributor.author	Díaz Llopis, Manuel	es_ES
dc.contributor.author	Millán Salvador, José María	es_ES
dc.contributor.author	Rodrigo, Regina	es_ES
dc.date.accessioned	2015-06-18T12:29:22Z
dc.date.available	2015-06-18T12:29:22Z
dc.date.issued	2013	es_ES
dc.identifier.citation	PLoS ONE Vol. 8 Issue 9:	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44478
dc.description.abstract	Retinitis Pigmentosa is a common form of hereditary retinal degeneration constituting the largest Mendelian genetic cause of blindness in the developed world. It has been widely suggested that oxidative stress possibly contributes to its pathogenesis. We measured the levels of total antioxidant capacity, free nitrotyrosine, thiobarbituric acid reactive substances (TBARS) formation, extracellular superoxide dismutase (SOD3) activity, protein, metabolites of the nitric oxide/cyclic GMP pathway, heme oxygenase-I and inducible nitric oxide synthase expression in aqueous humor or/and peripheral blood from fifty-six patients with retinitis pigmentosa and sixty subjects without systemic or ocular oxidative stress-related disease. Multivariate analysis of covariance revealed that retinitis pigmentosa alters ocular antioxidant defence machinery and the redox status in blood. Patients with retinitis pigmentosa present low total antioxidant capacity including reduced SOD3 activity and protein concentration in aqueous humor. Patients also show reduced SOD3 activity, increased TBARS formation and upregulation of the nitric oxide/cyclic GMP pathway in peripheral blood. Together these findings confirmed the hypothesis that patients with retinitis pigmentosa present reduced ocular antioxidant status. Moreover, these patients show changes in some oxidative-nitrosative markers in the peripheral blood. Further studies are needed to clarify the relationship between these peripheral markers and retinitis pigmentosa.	es_ES
dc.title	Altered Antioxidant-Oxidant Status in the Aqueous Humor and Peripheral Blood of Patients with Retinitis Pigmentosa	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1371/journal.pone.0074223	es_ES
dc.identifier.idgrec	091281	es_ES