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Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial

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Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial

dc.contributor.author	Toledo, Estefanía	es_ES
dc.contributor.author	Hu, Frank B.	es_ES
dc.contributor.author	Estruch, Ramón	es_ES
dc.contributor.author	Buil-Cosiales, Pilar	es_ES
dc.contributor.author	Corella, Dolores	es_ES
dc.contributor.author	Salas-Salvadó, Jordi	es_ES
dc.contributor.author	Covas, María-Isabel	es_ES
dc.contributor.author	Arós, Fernando	es_ES
dc.contributor.author	Gómez-Gracia, Enrique	es_ES
dc.contributor.author	Fiol, Miquel	es_ES
dc.contributor.author	Lapetra, José	es_ES
dc.contributor.author	Serra-Majem, Lluís	es_ES
dc.contributor.author	Pintó, Xavier	es_ES
dc.contributor.author	Lamuela-Raventós, Rosa Maria	es_ES
dc.contributor.author	Sáez Tormo, Guillermo	es_ES
dc.contributor.author	Bulló, Mònica	es_ES
dc.contributor.author	Ruiz-Gutiérrez, Valentina	es_ES
dc.contributor.author	Ros, Emilio	es_ES
dc.contributor.author	Sorlí Guerola, José Vicente	es_ES
dc.contributor.author	Martínez-González, Miguel Ángel	es_ES
dc.date.accessioned	2015-06-19T07:47:44Z
dc.date.available	2015-06-19T07:47:44Z
dc.date.issued	2013	es_ES
dc.identifier.citation	BMC Medicine Vol. 11 pp. 207-207	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44496
dc.description.abstract	BackgroundHypertension can be prevented by adopting healthy dietary patterns. Our aim was to assess the 4-year effect on blood pressure (BP) control of a randomized feeding trial promoting the traditional Mediterranean dietary pattern.MethodsThe PREDIMED primary prevention trial is a randomized, single-blinded, controlled trial conducted in Spanish primary healthcare centers. We recruited 7,447 men (aged 55 to 80 years) and women (aged 60 to 80 years) who had high risk for cardiovascular disease. Participants were assigned to a control group or to one of two Mediterranean diets. The control group received education on following a low-fat diet, while the groups on Mediterranean diets received nutritional education and also free foods; either extra virgin olive oil, or nuts. Trained personnel measured participants’ BP at baseline and once yearly during a 4-year follow-up. We used generalized estimating equations to assess the differences between groups during the follow-up.ResultsThe percentage of participants with controlled BP increased in all three intervention groups (P-value for within-group changes: P<0.001). Participants allocated to either of the two Mediterranean diet groups had significantly lower diastolic BP than the participants in the control group (−1.53 mmHg (95% confidence interval (CI) −2.01 to −1.04) for the Mediterranean diet supplemented with extra virgin olive oil, and −0.65 mmHg (95% CI -1.15 to −0.15) mmHg for the Mediterranean diet supplemented with nuts). No between-group differences in changes of systolic BP were seen.ConclusionsBoth the traditional Mediterranean diet and a low-fat diet exerted beneficial effects on BP and could be part of advice to patients for controlling BP. However, we found lower values of diastolic BP in the two groups promoting the Mediterranean diet with extra virgin olive oil or with nuts than in the control group.Trial registrationCurrent Controlled Trials ISRCTN35739639	es_ES
dc.subject	Mediterranean diet	es_ES
dc.subject	Low-fat diet	es_ES
dc.subject	Systolic blood pressure	es_ES
dc.subject	Diastolic blood pressure	es_ES
dc.subject	Controlled trial	es_ES
dc.subject	PREDIMED trial	es_ES
dc.subject	Monounsaturated fat	es_ES
dc.subject	Dietary patterns	es_ES
dc.subject	Olive oil	es_ES
dc.subject	Nuts	es_ES
dc.title	Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1186/1741-7015-11-207	es_ES
dc.identifier.idgrec	094230	es_ES