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Differential Effects of Antibiotic Therapy on the Structure and Function of Human Gut Microbiota

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Differential Effects of Antibiotic Therapy on the Structure and Function of Human Gut Microbiota

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dc.contributor.author Pérez-Cobas, Ana Elena es_ES
dc.contributor.author Artacho, Alejandro es_ES
dc.contributor.author Knecht, Henrik es_ES
dc.contributor.author Ferrús, María Loreto es_ES
dc.contributor.author Friedrichs, Anette es_ES
dc.contributor.author Ott, Stephan J. es_ES
dc.contributor.author Moya, Andrés es_ES
dc.contributor.author Latorre, Amparo es_ES
dc.contributor.author Gosalbes Soler, María José es_ES
dc.date.accessioned 2015-06-19T07:47:44Z
dc.date.available 2015-06-19T07:47:44Z
dc.date.issued 2013 es_ES
dc.identifier.citation PLoS ONE Vol. 8 Issue 11: es_ES
dc.identifier.uri http://hdl.handle.net/10550/44499
dc.description.abstract The human intestinal microbiota performs many essential functions for the host. Antimicrobial agents, such as antibiotics (AB), are also known to disturb microbial community equilibrium, thereby having an impact on human physiology. While an increasing number of studies investigate the effects of AB usage on changes in human gut microbiota biodiversity, its functional effects are still poorly understood. We performed a follow-up study to explore the effect of ABs with different modes of action on human gut microbiota composition and function. Four individuals were treated with different antibiotics and samples were taken before, during and after the AB course for all of them. Changes in the total and in the active (growing) microbiota as well as the functional changes were addressed by 16S rRNA gene and metagenomic 454-based pyrosequencing approaches. We have found that the class of antibiotic, particularly its antimicrobial effect and mode of action, played an important role in modulating the gut microbiota composition and function. Furthermore, analysis of the resistome suggested that oscillatory dynamics are not only due to antibiotic-target resistance, but also to fluctuations in the surviving bacterial community. Our results indicated that the effect of AB on the human gut microbiota relates to the interaction of several factors, principally the properties of the antimicrobial agent, and the structure, functions and resistance genes of the microbial community. es_ES
dc.title Differential Effects of Antibiotic Therapy on the Structure and Function of Human Gut Microbiota es_ES
dc.type journal article es_ES
dc.identifier.doi 10.1371/journal.pone.0080201 es_ES
dc.identifier.idgrec 094631 es_ES

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