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Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

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Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

dc.contributor.author	Cousminer, Diana L.	es_ES
dc.contributor.author	Berry, Diane J.	es_ES
dc.contributor.author	Timpson, Nicholas J.	es_ES
dc.contributor.author	Ang, Wei	es_ES
dc.contributor.author	Thiering, Elisabeth	es_ES
dc.contributor.author	Byrne, Enda M.	es_ES
dc.contributor.author	Taal, H. Rob	es_ES
dc.contributor.author	Huikari, Ville	es_ES
dc.contributor.author	Bradfield, Jonathan P.	es_ES
dc.contributor.author	Kerkhof, Marjan	es_ES
dc.contributor.author	Groen-Blokhuis, Maria M.	es_ES
dc.contributor.author	Kreiner-Møller, Eskil	es_ES
dc.contributor.author	Marinelli, Marcella	es_ES
dc.contributor.author	Holst, Claus	es_ES
dc.contributor.author	Leinonen, Jaakko T.	es_ES
dc.contributor.author	Perry, John R.B.	es_ES
dc.contributor.author	Surakka, Ida	es_ES
dc.contributor.author	Pietiläinen, Olli	es_ES
dc.contributor.author	Kettunen, Johannes	es_ES
dc.contributor.author	Anttila, Verneri	es_ES
dc.contributor.author	Kaakinen, Marika	es_ES
dc.contributor.author	Sovio, Ulla	es_ES
dc.contributor.author	Pouta, Anneli	es_ES
dc.contributor.author	Das, Shikta	es_ES
dc.contributor.author	Lagou, Vasiliki	es_ES
dc.contributor.author	Power, Chris	es_ES
dc.contributor.author	Prokopenko, Inga	es_ES
dc.contributor.author	Evans, David M.	es_ES
dc.contributor.author	Kemp, John P.	es_ES
dc.contributor.author	St Pourcain, Beate	es_ES
dc.contributor.author	Ring, Susan	es_ES
dc.contributor.author	Palotie, Aarno	es_ES
dc.contributor.author	Kajantie, Eero	es_ES
dc.contributor.author	Osmond, Clive	es_ES
dc.contributor.author	Lehtimäki, Terho	es_ES
dc.contributor.author	Viikari, Jorma S.	es_ES
dc.contributor.author	Kähönen, Mika	es_ES
dc.contributor.author	Warrington, Nicole M.	es_ES
dc.contributor.author	Lye, Stephen J.	es_ES
dc.contributor.author	Palmer, Lyle J.	es_ES
dc.contributor.author	Tiesler, Carla M.T.	es_ES
dc.contributor.author	Flexeder, Claudia	es_ES
dc.contributor.author	Montgomery, Grant W.	es_ES
dc.contributor.author	Medland, Sarah E.	es_ES
dc.contributor.author	Hofman, Albert	es_ES
dc.contributor.author	Hakonarson, Hakon	es_ES
dc.contributor.author	Guxens, Mònica	es_ES
dc.contributor.author	Bartels, Meike	es_ES
dc.contributor.author	Salomaa, Veikko	es_ES
dc.contributor.author	Murabito, Joanne M.	es_ES
dc.contributor.author	Kaprio, Jaakko	es_ES
dc.contributor.author	Sørensen, Thorkild I.A.	es_ES
dc.contributor.author	Ballester, Ferran	es_ES
dc.contributor.author	Bisgaard, Hans	es_ES
dc.contributor.author	Boomsma, Dorret I.	es_ES
dc.contributor.author	Koppelman, Gerard H.	es_ES
dc.contributor.author	Grant, Struan F.A.	es_ES
dc.contributor.author	Jaddoe, Vincent W.V.	es_ES
dc.contributor.author	Martin, Nicholas G.	es_ES
dc.contributor.author	Heinrich, Joachim	es_ES
dc.contributor.author	Pennell, Craig E.	es_ES
dc.contributor.author	Raitakari, Olli T.	es_ES
dc.contributor.author	Eriksson, Johan G.	es_ES
dc.contributor.author	Smith, George Davey	es_ES
dc.contributor.author	Hyppönen, Elina	es_ES
dc.contributor.author	Järvelin, Marjo-Riitta	es_ES
dc.contributor.author	McCarthy, Mark I.	es_ES
dc.contributor.author	Ripatti, Samuli	es_ES
dc.contributor.author	Widén, Elisabeth	es_ES
dc.date.accessioned	2015-06-19T07:47:45Z
dc.date.available	2015-06-19T07:47:45Z
dc.date.issued	2013	es_ES
dc.identifier.citation	Human Molecular Genetics Vol. 22 Issue 13: pp. 2735-2747	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44504
dc.description.abstract	The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared underlying mechanisms. To discover genetic loci influencing pubertal height and growth and to place them in context of overall growth and maturation, we performed genome-wide association meta-analyses in 18 737 European samples utilizing longitudinally collected height measurements. We found significant associations (P < 1.67 × 10−8) at 10 loci, including LIN28B. Five loci associated with pubertal timing, all impacting multiple aspects of growth. In particular, a novel variant correlated with expression of MAPK3, and associated both with increased prepubertal growth and earlier menarche. Another variant near ADCY3-POMC associated with increased body mass index, reduced pubertal growth and earlier puberty. Whereas epidemiological correlations suggest that early puberty marks a pathway from rapid prepubertal growth to reduced final height and adult obesity, our study shows that individual loci associating with pubertal growth have variable longitudinal growth patterns that may differ from epidemiological observations. Overall, this study uncovers part of the complex genetic architecture linking pubertal height growth, the timing of puberty and childhood obesity and provides new information to pinpoint processes linking these traits.	es_ES
dc.title	Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1093/hmg/ddt104	es_ES
dc.identifier.idgrec	094989	es_ES