NAGIOS: RODERIC FUNCIONANDO

Tyrosine Phosphorylation Modulates the Vascular Responses of Mesenteric Arteries from Human Colorectal Tumors

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Tyrosine Phosphorylation Modulates the Vascular Responses of Mesenteric Arteries from Human Colorectal Tumors

dc.contributor.author	Ferrero, Eduardo	es_ES
dc.contributor.author	Mauricio Aviñó, María Dolores	es_ES
dc.contributor.author	Granado, Miriam	es_ES
dc.contributor.author	García-Villar, Oscar	es_ES
dc.contributor.author	Aldasoro Celaya, Martín	es_ES
dc.contributor.author	Vila Salinas, José María	es_ES
dc.contributor.author	Hidalgo, Manuel	es_ES
dc.contributor.author	Ferrero, Jorge Luis	es_ES
dc.contributor.author	Fernández, Nuria	es_ES
dc.contributor.author	Monge, Luis	es_ES
dc.contributor.author	García-Villalón, Ángel Luis	es_ES
dc.date.accessioned	2015-06-19T07:47:46Z
dc.date.available	2015-06-19T07:47:46Z
dc.date.issued	2013	es_ES
dc.identifier.citation	BioMed Research International Vol. 2013	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44510
dc.description.abstract	The aim of this study was to analyze whether tyrosine phosphorylation in tumoral arteries may modulate their vascular response. To do this, mesenteric arteries supplying blood flow to colorectal tumors or to normal intestine were obtained during surgery and prepared for isometric tension recording in an organ bath. Increasing tyrosine phosphorylation with the phosphatase inhibitor, sodium orthovanadate produced arterial contraction which was lower in tumoral than in control arteries, whereas it reduced the contraction to noradrenaline in tumoral but not in control arteries and reduced the relaxation to bradykinin in control but not in tumoral arteries. Protein expression of VEGF-A and of the VEGF receptor FLT1 was similar in control and tumoral arteries, but expression of the VEGF receptor KDR was increased in tumoral compared with control arteries. This suggests that tyrosine phosphorylation may produce inhibition of the contraction in tumoral mesenteric arteries, which may increase blood flow to the tumor when tyrosine phosphorylation is increased by stimulation of VEGF receptors.	es_ES
dc.title	Tyrosine Phosphorylation Modulates the Vascular Responses of Mesenteric Arteries from Human Colorectal Tumors	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1155/2013/545983	es_ES
dc.identifier.idgrec	097253	es_ES