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Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis

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Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis

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dc.contributor.author Guirado Guillén, Ramón es_ES
dc.contributor.author Sanchez-Matarredona, David es_ES
dc.contributor.author Varea López, Emilio es_ES
dc.contributor.author Crespo Rupérez, Carlos es_ES
dc.contributor.author Blasco Ibáñez, José Miguel es_ES
dc.contributor.author Nácher Roselló, Juan Salvador es_ES
dc.date.accessioned 2015-06-19T10:17:58Z
dc.date.available 2015-06-19T10:17:58Z
dc.date.issued 2012 es_ES
dc.identifier.citation BMC Neuroscience Vol. 13 pp. 5-5 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44532
dc.description.abstract BackgroundAntidepressants promote neuronal structural plasticity in young-adult rodents, but little is known of their effects on older animals. The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) may mediate these structural changes through its anti-adhesive properties. PSA-NCAM is expressed in immature neurons and in a subpopulation of mature interneurons and its expression is modulated by antidepressants in the telencephalon of young-adult rodents.ResultsWe have analyzed the effects of 14 days of fluoxetine treatment on the density of puncta expressing PSA-NCAM and different presynaptic markers in the medial prefrontal cortex, hippocampus and amygdala of middle-aged (8 months old) rats. The density of puncta expressing PSA-NCAM increased in the dorsal cingulate cortex, as well as in different hippocampal and amygdaloid regions. In these later regions there were also increases in the density of puncta expressing glutamic acid decarboxylase 65/67 (GAD6), synaptophysin (SYN), PSA-NCAM/SYN and PSA-NCAM/GAD6, but a decrease of those expressing vesicular glutamate transporter 1 (VGluT1). Since there is controversy on the effects of antidepressants on neurogenesis during aging, we analyzed the number of proliferating cells expressing Ki67 and that of immature neurons expressing doublecortin or PSA-NCAM. No significant changes were found in the subgranular zone, but the number of proliferating cells decreased in the subventricular zone.ConclusionsThese results indicate that the effects of fluoxetine in middle-aged rats are different to those previously described in young-adult animals, being more restricted in the mPFC and even following an opposite direction in the amygdala or the subventricular zone. es_ES
dc.title Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis es_ES
dc.type journal article es_ES
dc.identifier.doi 10.1186/1471-2202-13-5 es_ES
dc.identifier.idgrec 075640 es_ES
dc.identifier.idgrec 076813
dc.identifier.idgrec 076182

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