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A Polymorphism in a Gene Encoding Perilipin 4 Is Associated with Height but not with Bone Measures in Individuals from the Framingham Osteoporosis Study

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A Polymorphism in a Gene Encoding Perilipin 4 Is Associated with Height but not with Bone Measures in Individuals from the Framingham Osteoporosis Study

dc.contributor.author	Cusano, Natalie E.	es_ES
dc.contributor.author	Kiel, Douglas P.	es_ES
dc.contributor.author	Demissie, Serkalem	es_ES
dc.contributor.author	Karasik, David	es_ES
dc.contributor.author	Cupples, L. Adrienne	es_ES
dc.contributor.author	Corella, Dolores	es_ES
dc.contributor.author	Gao, Qiong	es_ES
dc.contributor.author	Richardson, Kris	es_ES
dc.contributor.author	Yiannakouris, Nikos	es_ES
dc.contributor.author	Ordovas, Jose M.	es_ES
dc.date.accessioned	2015-06-19T10:17:58Z
dc.date.available	2015-06-19T10:17:58Z
dc.date.issued	2012	es_ES
dc.identifier.citation	Calcified tissue international Vol. 90 Issue 2: pp. 96-107	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44534
dc.description.abstract	There is increasing interest in identifying new pathways and candidate genes that confer susceptibility to osteoporosis. There is evidence that adipogenesis and osteogenesis may be related, including a common bone marrow progenitor cell for both adipocytes and osteoblasts. Perilipin 1 (PLIN1) and Perilipin 4 (PLIN4) are members of the PATS family of genes and are involved in lipolysis of intracellular lipid deposits. A previous study reported gender-specific associations between one polymorphism of PLIN1 and bone mineral density (BMD) in a Japanese population. We hypothesized that polymorphisms in PLIN1 and PLIN4 would be associated with bone measures in adult Caucasian participants of the Framingham Osteoporosis Study (FOS). We genotyped 1,206 male and 1,445 female participants of the FOS for four single-nucleotide polymorphism (SNPs) in PLIN1 and seven SNPs in PLIN4 and tested for associations with measures of BMD, bone ultrasound, hip geometry, and height. We found several gender-specific significant associations with the measured traits. The association of PLIN4 SNP rs8887, G>A with height in females trended toward significance after simulation testing (adjusted P = 0.07) and remained significant after simulation testing in the combined-sex model (adjusted P = 0.033). In a large study sample of men and women, we found a significant association between one SNP in PLIN4 and height but not with bone traits, suggesting that PATS family genes are not important in the regulation of bone. Identification of genes that influence human height may lead to a better understanding of the processes involved in growth and development.	es_ES
dc.subject	Perilipin 1	es_ES
dc.subject	Perilipin 4	es_ES
dc.subject	Bone mineral density	es_ES
dc.subject	Bone geometry	es_ES
dc.subject	Framingham Osteoporosis Study	es_ES
dc.title	A Polymorphism in a Gene Encoding Perilipin 4 Is Associated with Height but not with Bone Measures in Individuals from the Framingham Osteoporosis Study	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1007/s00223-011-9552-7	es_ES
dc.identifier.idgrec	076267	es_ES