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Physiologic Expression of the Candida albicans Pescadillo Homolog Is Required for Virulence in a Murine Model of Hematogenously Disseminated Candidiasis

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Physiologic Expression of the Candida albicans Pescadillo Homolog Is Required for Virulence in a Murine Model of Hematogenously Disseminated Candidiasis

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dc.contributor.author Uppuluri, Priya es_ES
dc.contributor.author Chaturvedi, Ashok K. es_ES
dc.contributor.author Jani, Niketa es_ES
dc.contributor.author Pukkila-Worley, Read es_ES
dc.contributor.author Monteagudo Castro, Carlos es_ES
dc.contributor.author Mylonakis, Eleftherios es_ES
dc.contributor.author Köhler, Julia R. es_ES
dc.contributor.author López-Ribot, Jose Luis es_ES
dc.date.accessioned 2015-06-19T10:18:00Z
dc.date.available 2015-06-19T10:18:00Z
dc.date.issued 2012 es_ES
dc.identifier.citation Eukaryotic Cell Vol. 11 Issue 12: pp. 1552-1556 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44549
dc.description.abstract Morphogenetic conversions contribute to the pathogenesis of Candida albicans invasive infections. Many studies to date have convincingly demonstrated a link between filamentation and virulence; however, relatively little is known regarding the role of the filament-to-yeast transition during the pathogenesis of invasive candidiasis. We previously identified the C. albicans pescadillo homolog (PES1) as essential during yeast growth and growth of lateral yeast on hyphae but not during hyphal growth. Furthermore, we demonstrated that PES1 is required for virulence in vivo in a Galleria mellonella larva model of candidiasis. Here, we have used a regulatable tetO-PES1/pes1 strain to assess the contribution of C. albicansPES1 to pathogenesis in the commonly used and clinically relevant murine model of hematogenously disseminated candidiasis. Our results indicate that a physiologically controlled level of PES1 expression is required for full virulence in this animal model, with virulence defects observed both when PES1 is overexpressed and and when it is depleted. The pathogenetic defect of cells depleted of PES1 is not due to a general growth defect, as demonstrated by the fact that PES1-depleted cells still kill Caenorhabditis elegans as efficiently as the wild type due to hyphal outgrowth through worm tissues. Our results suggest a critical role of lateral yeast growth in the ability of C. albicans to normally proliferate within tissues, as well as a pivotal role for Pes1 in the normal developmental cycle of C. albicans within the mammalian host during infection. es_ES
dc.title Physiologic Expression of the Candida albicans Pescadillo Homolog Is Required for Virulence in a Murine Model of Hematogenously Disseminated Candidiasis es_ES
dc.type journal article es_ES
dc.identifier.doi 10.1128/EC.00171-12 es_ES
dc.identifier.idgrec 083968 es_ES

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