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Detection methods predict differences in biology and survival in breast cancer patients

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Detection methods predict differences in biology and survival in breast cancer patients

dc.contributor.author	Redondo, Maximino	es_ES
dc.contributor.author	Funez, Rafael	es_ES
dc.contributor.author	Medina-Cano, Francisco	es_ES
dc.contributor.author	Rodrigo, Isabel	es_ES
dc.contributor.author	Acebal, Mercedes	es_ES
dc.contributor.author	Tellez, Teresa	es_ES
dc.contributor.author	Roldan, M. Jose	es_ES
dc.contributor.author	Hortas, M. Luisa	es_ES
dc.contributor.author	Bellinvia, Ana	es_ES
dc.contributor.author	Pereda, Teresa	es_ES
dc.contributor.author	Domingo, Laia	es_ES
dc.contributor.author	Morales Suárez-Varela, María M.	es_ES
dc.contributor.author	Sala, Maria	es_ES
dc.contributor.author	Rueda, Antonio	es_ES
dc.date.accessioned	2015-06-19T10:19:54Z
dc.date.available	2015-06-19T10:19:54Z
dc.date.issued	2012	es_ES
dc.identifier.citation	BMC Cancer Vol. 12 pp. 604-604	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44557
dc.description.abstract	BackgroundThe aim of this study was to measure the biological characteristics involved in tumorigenesis and the progression of breast cancer in symptomatic and screen-detected carcinomas to identify possible differences.MethodsFor this purpose, we evaluated clinical-pathological parameters and proliferative and apoptotic activities in a series of 130 symptomatic and 161 screen-detected tumors.ResultsAfter adjustment for the smaller size of the screen-detected carcinomas compared with symptomatic cancers, those detected in the screening program presented longer disease-free survival (RR = 0.43, CI = 0.19-0.96) and had high estrogen and progesterone receptor concentrations more often than did symptomatic cancers (OR = 3.38, CI = 1.72-6.63 and OR = 3.44, CI = 1.94-6.10, respectively). Furthermore, the expression of bcl-2, a marker of good prognosis in breast cancer, was higher and HER2/neu expression was lower in screen-detected cancers than in symptomatic cancers (OR = 1.77, CI = 1.01-3.23 and OR = 0.64, CI = 0.40-0.98, respectively). However, when comparing prevalent vs incident screen-detected carcinomas, prevalent tumors were larger (OR = 2.84, CI = 1.05-7.69), were less likely to be HER2/neu positive (OR = 0.22, CI = 0.08-0.61) and presented lower Ki67 expression (OR = 0.36, CI = 0.17-0.77). In addition, incident tumors presented a shorter survival time than did prevalent ones (RR = 4.88, CI = 1.12-21.19).ConclusionsIncident carcinomas include a variety of screen-detected carcinomas that exhibit differences in biology and prognosis relative to prevalent carcinomas. The detection method is important and should be taken into account when making therapy decisions.	es_ES
dc.subject	Breast cancer	es_ES
dc.subject	Detection methods	es_ES
dc.subject	Proliferation	es_ES
dc.subject	Apoptosis	es_ES
dc.subject	Survival	es_ES
dc.title	Detection methods predict differences in biology and survival in breast cancer patients	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1186/1471-2407-12-604	es_ES
dc.identifier.idgrec	084751	es_ES