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Strategies for annotation and curation of translational databases: the eTUMOUR project

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Strategies for annotation and curation of translational databases: the eTUMOUR project

dc.contributor.author	Julià-Sapé, Margarida	es_ES
dc.contributor.author	Lurgi, Miguel	es_ES
dc.contributor.author	Mier, Mariola	es_ES
dc.contributor.author	Estanyol, Francesc	es_ES
dc.contributor.author	Rafael, Xavier	es_ES
dc.contributor.author	Candiota, Ana Paula	es_ES
dc.contributor.author	Barceló, Anna	es_ES
dc.contributor.author	García, Alina	es_ES
dc.contributor.author	Martínez Bisbal, María Carmen	es_ES
dc.contributor.author	Ferrer-Luna, Rubén	es_ES
dc.contributor.author	Moreno-Torres, Àngel	es_ES
dc.contributor.author	Celda Muñoz, Bernardo	es_ES
dc.contributor.author	Arús, Carles	es_ES
dc.date.accessioned	2015-06-19T10:21:22Z
dc.date.available	2015-06-19T10:21:22Z
dc.date.issued	2012	es_ES
dc.identifier.citation	Database: The Journal of Biological Databases and Curation Vol. 2012	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44571
dc.description.abstract	The eTUMOUR (eT) multi-centre project gathered in vivo and ex vivo magnetic resonance (MR) data, as well as transcriptomic and clinical information from brain tumour patients, with the purpose of improving the diagnostic and prognostic evaluation of future patients. In order to carry this out, among other work, a database—the eTDB—was developed. In addition to complex permission rules and software and management quality control (QC), it was necessary to develop anonymization, processing and data visualization tools for the data uploaded. It was also necessary to develop sophisticated curation strategies that involved on one hand, dedicated fields for QC-generated meta-data and specialized queries and global permissions for senior curators and on the other, to establish a set of metrics to quantify its contents. The indispensable dataset (ID), completeness and pairedness indices were set. The database contains 1317 cases created as a result of the eT project and 304 from a previous project, INTERPRET. The number of cases fulfilling the ID was 656. Completeness and pairedness were heterogeneous, depending on the data type involved.	es_ES
dc.title	Strategies for annotation and curation of translational databases: the eTUMOUR project	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1093/database/bas035	es_ES
dc.identifier.idgrec	087956	es_ES