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Neurons of the Dentate Molecular Layer in the Rabbit Hippocampus

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Neurons of the Dentate Molecular Layer in the Rabbit Hippocampus

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dc.contributor.author Sancho-Bielsa, Francisco J. es_ES
dc.contributor.author Navarro-López, Juan D. es_ES
dc.contributor.author Alonso-Llosa, Gregori es_ES
dc.contributor.author Molowny, Asunción es_ES
dc.contributor.author Ponsoda i Martí, Xavier es_ES
dc.contributor.author Yajeya, Javier es_ES
dc.contributor.author López-García, Carlos es_ES
dc.date.accessioned 2015-06-19T10:21:23Z
dc.date.available 2015-06-19T10:21:23Z
dc.date.issued 2012 es_ES
dc.identifier.citation PLoS ONE Vol. 7 Issue 11: es_ES
dc.identifier.uri http://hdl.handle.net/10550/44579
dc.description.abstract The molecular layer of the dentate gyrus appears as the main entrance gate for information into the hippocampus, i.e., where the perforant path axons from the entorhinal cortex synapse onto the spines and dendrites of granule cells. A few dispersed neuronal somata appear intermingled in between and probably control the flow of information in this area. In rabbits, the number of neurons in the molecular layer increases in the first week of postnatal life and then stabilizes to appear permanent and heterogeneous over the individuals’ life span, including old animals. By means of Golgi impregnations, NADPH histochemistry, immunocytochemical stainings and intracellular labelings (lucifer yellow and biocytin injections), eight neuronal morphological types have been detected in the molecular layer of developing adult and old rabbits. Six of them appear as interneurons displaying smooth dendrites and GABA immunoreactivity: those here called as globoid, vertical, small horizontal, large horizontal, inverted pyramidal and polymorphic. Additionally there are two GABA negative types: the sarmentous and ectopic granular neurons. The distribution of the somata and dendritic trees of these neurons shows preferences for a definite sublayer of the molecular layer: small horizontal, sarmentous and inverted pyramidal neurons are preferably found in the outer third of the molecular layer; vertical, globoid and polymorph neurons locate the intermediate third, while large horizontal and ectopic granular neurons occupy the inner third or the juxtagranular molecular layer. Our results reveal substantial differences in the morphology and electrophysiological behaviour between each neuronal archetype in the dentate molecular layer, allowing us to propose a new classification for this neural population. es_ES
dc.title Neurons of the Dentate Molecular Layer in the Rabbit Hippocampus es_ES
dc.type journal article es_ES
dc.identifier.doi 10.1371/journal.pone.0048470 es_ES
dc.identifier.idgrec 089536 es_ES
dc.identifier.idgrec 086784
dc.identifier.idgrec 089508

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