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Amygdaloid Projections to the Ventral Striatum in Mice: Direct and Indirect Chemosensory Inputs to the Brain Reward System

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Amygdaloid Projections to the Ventral Striatum in Mice: Direct and Indirect Chemosensory Inputs to the Brain Reward System

dc.contributor.author	Novejarque, Amparo	es_ES
dc.contributor.author	Gutiérrez-Castellanos, Nicolás	es_ES
dc.contributor.author	Lanuza Navarro, Enrique	es_ES
dc.contributor.author	Martínez-García, Fernando	es_ES
dc.date.accessioned	2015-06-22T09:46:04Z
dc.date.available	2015-06-22T09:46:04Z
dc.date.issued	2011	es_ES
dc.identifier.citation	Frontiers in Neuroanatomy Vol. 5	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44652
dc.description.abstract	Rodents constitute good models for studying the neural basis of sociosexual behavior. Recent findings in mice have revealed the molecular identity of the some pheromonal molecules triggering intersexual attraction. However, the neural pathways mediating this basic sociosexual behavior remain elusive. Since previous work indicates that the dopaminergic tegmento-striatal pathway is not involved in pheromone reward, the present report explores alternative pathways linking the vomeronasal system with the tegmento-striatal system (the limbic basal ganglia) by means of tract-tracing experiments studying direct and indirect projections from the chemosensory amygdala to the ventral striato-pallidum. Amygdaloid projections to the nucleus accumbens, olfactory tubercle, and adjoining structures are studied by analyzing the retrograde transport in the amygdala from dextran amine and fluorogold injections in the ventral striatum, as well as the anterograde labeling found in the ventral striato-pallidum after dextran amine injections in the amygdala. This combination of anterograde and retrograde tracing experiments reveals direct projections from the vomeronasal cortex to the ventral striato-pallidum, as well as indirect projections through different nuclei of the basolateral amygdala. Direct projections innervate mainly the olfactory tubercle and the islands of Calleja, whereas indirect projections are more widespread and reach the same structures and the shell and core of nucleus accumbens. These pathways are likely to mediate innate responses to pheromones (direct projections) and conditioned responses to associated chemosensory and non-chemosensory stimuli (indirect projections). Comparative studies indicate that similar connections are present in all the studied amniote vertebrates and might constitute the basic circuitry for emotional responses to conspecifics in most vertebrates, including humans.	es_ES
dc.subject	chemosensory amygdala	es_ES
dc.subject	nucleus accumbens	es_ES
dc.subject	olfactory tubercle	es_ES
dc.subject	islands of Calleja	es_ES
dc.subject	striatal cell bridges	es_ES
dc.subject	emotional brain	es_ES
dc.title	Amygdaloid Projections to the Ventral Striatum in Mice: Direct and Indirect Chemosensory Inputs to the Brain Reward System	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.3389/fnana.2011.00054	es_ES
dc.identifier.idgrec	068241	es_ES