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How to minimise the effect of tumour cell content in detection of aberrant genetic markers in neuroblastoma

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How to minimise the effect of tumour cell content in detection of aberrant genetic markers in neuroblastoma

dc.contributor.author	Piqueras, M.	es_ES
dc.contributor.author	Navarro, S.	es_ES
dc.contributor.author	Cañete Nieto, Adela	es_ES
dc.contributor.author	Castel Sánchez, Victoria	es_ES
dc.contributor.author	Noguera Salvá, Rosa	es_ES
dc.date.accessioned	2015-06-22T09:50:04Z
dc.date.available	2015-06-22T09:50:04Z
dc.date.issued	2011	es_ES
dc.identifier.citation	British Journal of Cancer Vol. 105 Issue 1: pp. 89-92	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44655
dc.description.abstract	Background:Clinical heterogeneity reflects the complexity of genetic events associated with neuroblastoma (NB). To identify the status of all described genetic loci with possible prognostic interest, high-throughput approaches have been used, but only with tumour cell content >60%. In some tumours, necrotic, haemorrhagic and/or calcification areas influence the low amount of neuroblasts. We evaluated the effect of tumour cell content in the detection of relevant aberrant genetic markers (AGM) diagnosed by fluorescence in situ hybridisation (FISH) on tissue microarrays (TMA) in NB.Methods:Two hundred and thirty-three MYCN non-amplified primary NB included in 12 TMAs were analysed.Results:Presence of AGM reduced event-free survival (EFS) (P=0.004) as well as overall survival (OS) (P=0.004) of patients in the whole cohort. There were no differences in prognostic impact of presence of AGM according to tumour cell content.Conclusion:We propose the use of FISH to diagnose AGM of all NB samples having the above-mentioned areas to determine patient risk.	es_ES
dc.subject	neuroblastoma	es_ES
dc.subject	aberrant genetic markers	es_ES
dc.subject	FISH	es_ES
dc.subject	tumour cell content	es_ES
dc.subject	prognostic factors	es_ES
dc.title	How to minimise the effect of tumour cell content in detection of aberrant genetic markers in neuroblastoma	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1038/bjc.2011.188	es_ES
dc.identifier.idgrec	068659	es_ES