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The optimal age for performing surgery on patients with MEN 2B syndrome

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The optimal age for performing surgery on patients with MEN 2B syndrome

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dc.contributor.author Gómez i Gavara, C. es_ES
dc.contributor.author Ponce Marco, José Luis es_ES
dc.contributor.author Belda Ibáñez, Tatiana es_ES
dc.contributor.author Boscà Robledo, Andrea es_ES
dc.contributor.author Sebastian Pastor, C. es_ES
dc.contributor.author Navarro Milla, R. es_ES
dc.contributor.author Caballero Soto, María es_ES
dc.contributor.author Meseguer Anastasio, Manuel Francisco es_ES
dc.date.accessioned 2015-06-22T09:51:16Z
dc.date.available 2015-06-22T09:51:16Z
dc.date.issued 2011 es_ES
dc.identifier.citation Oncology Letters Vol. 2 Issue 5: pp. 929-930 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44671
dc.description.abstract Multiple endocrine neoplasia (MEN) syndromes are characterized by the association of various endocrine neoplasias. Prophylactic thyroidectomy is the treatment of choice for patients with RET gene mutations. The age at which patients undergo prophylactic thyroidectomy may vary depending on the position of the RET gene codon. In cases of MEN 2B, when the mutation is carried in codons 883, 918 or 922, prophylactic thyroidectomy is performed prior to 6 months of age, due to the increased aggressiveness of these heterozygosities, which are capable of determining the onset of medullary cancer during the first months of life. We present two heterozygous twin patients with MEN 2B syndrome who were born 32 weeks premature, and who underwent prophylactic thyroidectomy at 7 months of age. The patients were carriers of the mutation at codon 918. We suggested the early surgery at 7 months as, due to their prematurity, the patients were required to gain weight to improve their condition prior to surgery. The two patients had medullary thyroid carcinoma without lymph node involvement. In conclusion, for a truly prophylactic thyroidectomy, such patients should undergo surgery within the first month of life, particularly if these patients are carriers of the mutation in codons 883, 918 or 922. es_ES
dc.title The optimal age for performing surgery on patients with MEN 2B syndrome es_ES
dc.type journal article es_ES
dc.identifier.doi 10.3892/ol.2011.332 es_ES
dc.identifier.idgrec 074353 es_ES

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