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Common variants at VRK2 and TCF4 conferring risk of schizophrenia

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Common variants at VRK2 and TCF4 conferring risk of schizophrenia

dc.contributor.author	Steinberg, Stacy	es_ES
dc.contributor.author	de Jong, Simone	es_ES
dc.contributor.author	Andreassen, Ole A.	es_ES
dc.contributor.author	Werge, Thomas	es_ES
dc.contributor.author	Børglum, Anders D.	es_ES
dc.contributor.author	Mors, Ole	es_ES
dc.contributor.author	Mortensen, Preben B.	es_ES
dc.contributor.author	Gustafsson, Omar	es_ES
dc.contributor.author	Costas, Javier	es_ES
dc.contributor.author	Pietiläinen, Olli P. H.	es_ES
dc.contributor.author	Demontis, Ditte	es_ES
dc.contributor.author	Papiol, Sergi	es_ES
dc.contributor.author	Huttenlocher, Johanna	es_ES
dc.contributor.author	Mattheisen, Manuel	es_ES
dc.contributor.author	Breuer, René	es_ES
dc.contributor.author	Vassos, Evangelos	es_ES
dc.contributor.author	Giegling, Ina	es_ES
dc.contributor.author	Fraser, Gillian	es_ES
dc.contributor.author	Walker, Nicholas	es_ES
dc.contributor.author	Tuulio-Henriksson, Annamari	es_ES
dc.contributor.author	Suvisaari, Jaana	es_ES
dc.contributor.author	Lönnqvist, Jouko	es_ES
dc.contributor.author	Paunio, Tiina	es_ES
dc.contributor.author	Agartz, Ingrid	es_ES
dc.contributor.author	Melle, Ingrid	es_ES
dc.contributor.author	Djurovic, Srdjan	es_ES
dc.contributor.author	Strengman, Eric	es_ES
dc.contributor.author	Jürgens, Gesche	es_ES
dc.contributor.author	Glenthøj, Birte	es_ES
dc.contributor.author	Terenius, Lars	es_ES
dc.contributor.author	Hougaard, David M.	es_ES
dc.contributor.author	Ørntoft, Torben	es_ES
dc.contributor.author	Wiuf, Carsten	es_ES
dc.contributor.author	Didriksen, Michael	es_ES
dc.contributor.author	Hollegaard, Mads V.	es_ES
dc.contributor.author	Nordentoft, Merete	es_ES
dc.contributor.author	van Winkel, Ruud	es_ES
dc.contributor.author	Kenis, Gunter	es_ES
dc.contributor.author	Abramova, Lilia	es_ES
dc.contributor.author	Kaleda, Vasily	es_ES
dc.contributor.author	Arrojo, Manuel	es_ES
dc.contributor.author	Sanjuán Arias, Julio	es_ES
dc.contributor.author	Arango, Celso	es_ES
dc.contributor.author	Sperling, Swetlana	es_ES
dc.contributor.author	Rossner, Moritz	es_ES
dc.contributor.author	Ribolsi, Michele	es_ES
dc.contributor.author	Magni, Valentina	es_ES
dc.contributor.author	Siracusano, Alberto	es_ES
dc.contributor.author	Christiansen, Claus	es_ES
dc.contributor.author	Kiemeney, Lambertus A.	es_ES
dc.contributor.author	Veldink, Jan	es_ES
dc.contributor.author	van den Berg, Leonard	es_ES
dc.contributor.author	Ingason, Andres	es_ES
dc.contributor.author	Muglia, Pierandrea	es_ES
dc.contributor.author	Murray, Robin	es_ES
dc.contributor.author	Nöthen, Markus M.	es_ES
dc.contributor.author	Sigurdsson, Engilbert	es_ES
dc.contributor.author	Petursson, Hannes	es_ES
dc.contributor.author	Thorsteinsdottir, Unnur	es_ES
dc.contributor.author	Kong, Augustine	es_ES
dc.contributor.author	Rubino, I. Alex	es_ES
dc.contributor.author	De Hert, Marc	es_ES
dc.contributor.author	Réthelyi, János M.	es_ES
dc.contributor.author	Bitter, István	es_ES
dc.contributor.author	Jönsson, Erik G.	es_ES
dc.contributor.author	Golimbet, Vera	es_ES
dc.contributor.author	Carracedo, Angel	es_ES
dc.contributor.author	Ehrenreich, Hannelore	es_ES
dc.contributor.author	Craddock, Nick	es_ES
dc.contributor.author	Owen, Michael J.	es_ES
dc.contributor.author	O'Donovan, Michael C.	es_ES
dc.contributor.author	Ruggeri, Mirella	es_ES
dc.contributor.author	Tosato, Sarah	es_ES
dc.contributor.author	Peltonen, Leena	es_ES
dc.contributor.author	Ophoff, Roel A.	es_ES
dc.contributor.author	Collier, David A.	es_ES
dc.contributor.author	St Clair, David	es_ES
dc.contributor.author	Rietschel, Marcella	es_ES
dc.contributor.author	Cichon, Sven	es_ES
dc.contributor.author	Stefansson, Hreinn	es_ES
dc.contributor.author	Rujescu, Dan	es_ES
dc.contributor.author	Stefansson, Kari	es_ES
dc.date.accessioned	2015-06-22T09:51:17Z
dc.date.available	2015-06-22T09:51:17Z
dc.date.issued	2011	es_ES
dc.identifier.citation	Human Molecular Genetics Vol. 20 Issue 20: pp. 4076-4081	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44673
dc.description.abstract	Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10−9] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10−9).	es_ES
dc.title	Common variants at VRK2 and TCF4 conferring risk of schizophrenia	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1093/hmg/ddr325	es_ES
dc.identifier.idgrec	075243	es_ES