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A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI123

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A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI123

dc.contributor.author	Corella, Dolores	es_ES
dc.contributor.author	Arnett, Donna K.	es_ES
dc.contributor.author	Tucker, Katherine L.	es_ES
dc.contributor.author	Kabagambe, Edmond K.	es_ES
dc.contributor.author	Tsai, Michael	es_ES
dc.contributor.author	Parnell, Laurence D.	es_ES
dc.contributor.author	Lai, Chao-Qiang	es_ES
dc.contributor.author	Lee, Yu-Chi	es_ES
dc.contributor.author	Warodomwichit, Daruneewan	es_ES
dc.contributor.author	Hopkins, Paul N.	es_ES
dc.contributor.author	Ordovas, Jose M.	es_ES
dc.date.accessioned	2015-06-22T09:51:18Z
dc.date.available	2015-06-22T09:51:18Z
dc.date.issued	2011	es_ES
dc.identifier.citation	The Journal of Nutrition Vol. 141 Issue 12: pp. 2219-2225	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44679
dc.description.abstract	Evidence that physical activity (PA) modulates the association between the fat mass and obesity-associated gene (FTO) and BMI is emerging; however, information about dietary factors modulating this association is scarce. We investigated whether fat and carbohydrate intake modified the association of FTO gene variation with BMI in two populations, including participants in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 1069) and in the Boston Puerto Rican Health (BPRHS) study (n = 1094). We assessed energy, nutrient intake, and PA using validated questionnaires. Genetic variability at the FTO locus was characterized by polymorphisms rs9939609 (in the GOLDN) and rs1121980 (in the GOLDN and BPRHS). We found significant interactions between PA and FTO on BMI in the GOLDN but not in the BPRHS. We found a significant interaction between SFA intake and FTO on BMI, which was stronger than that of total fat and was present in both populations (P-interaction = 0.007 in the GOLDN and P-interaction = 0.014 in BPRHS for categorical; and P-interaction = 0.028 in the GOLDN and P-interaction = 0.041 in BPRHS for continuous SFA). Thus, homozygous participants for the FTO-risk allele had a higher mean BMI than the other genotypes only when they had a high-SFA intake (above the population mean: 29.7 ± 0.7 vs. 28.1 ± 0.5 kg/m2; P = 0.037 in the GOLDN and 33.6. ± 0.8 vs. 31.2 ± 0.4 kg/m2; P = 0.006 in BPRHS). No associations with BMI were found at lower SFA intakes. We found no significant interactions with carbohydrate intake. In conclusion, SFA intake modulates the association between FTO and BMI in American populations.	es_ES
dc.title	A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI123	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.3945/jn.111.143826	es_ES
dc.identifier.idgrec	076270	es_ES