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Contemporary genetic technologies and female reproduction

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Contemporary genetic technologies and female reproduction

dc.contributor.author	Fauser, B.C.J.M.	es_ES
dc.contributor.author	Diedrich, K.	es_ES
dc.contributor.author	Bouchard, P.	es_ES
dc.contributor.author	Domínguez, F.	es_ES
dc.contributor.author	Matzuk, M.	es_ES
dc.contributor.author	Franks, S.	es_ES
dc.contributor.author	Hamamah, S.	es_ES
dc.contributor.author	Simón Vallés, Carlos	es_ES
dc.contributor.author	Devroey, P.	es_ES
dc.contributor.author	Ezcurra, D.	es_ES
dc.contributor.author	Howles, C.M.	es_ES
dc.date.accessioned	2015-06-22T09:52:41Z
dc.date.available	2015-06-22T09:52:41Z
dc.date.issued	2011	es_ES
dc.identifier.citation	Human Reproduction Update Vol. 17 Issue 6: pp. 829-847	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44685
dc.description.abstract	BACKGROUNDThe Fifth Evian Annual Reproduction (EVAR) Workshop Meeting discussed knowledge regarding contemporary genetics in female reproduction.METHODSSpecialist reproductive medicine clinicians and geneticists delivered presentations based on published literature and current research. The content of this report is based on the expert presentations and subsequent group discussions that took place during this Workshop.RESULTSNumerous ovarian genes with a role in infertility have been identified. Future challenges for genetic screening of patients, such as those with polycystic ovary syndrome, primary ovarian insufficiency or endometriosis, include the identification of high-throughput strategies and how to apply these findings to infertile patients. The identification of high-quality embryos in IVF using objective technologies remains a high priority in order to facilitate single-embryo transfer. Gene expression profiling of cumulus cells surrounding the oocyte, and proteomic and metabolomic approaches in embryo culture media may significantly improve non-invasive embryo quality assessment.CONCLUSIONSThe way forward in advancing the knowledge of genes involved in reproduction was considered to be through genome-wide association studies involving large numbers of patients. Establishing international collaboration is required to enable the application of such technologies in sufficient numbers of patients.	es_ES
dc.subject	genes and female reproductive pathologies	es_ES
dc.subject	embryo assessment	es_ES
dc.subject	endometriosis	es_ES
dc.subject	metabolomics	es_ES
dc.subject	transcriptomics	es_ES
dc.title	Contemporary genetic technologies and female reproduction	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1093/humupd/dmr033	es_ES
dc.identifier.idgrec	076920	es_ES